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Record W4407688356 · doi:10.1093/brain/awaf053

Challenges and opportunities for advancing functional MRI in clinical practice

2025· article· en· W4407688356 on OpenAlexaff
Natalie Voets, Cathy J. Price, Matthew F. Glasser, Christopher Benjamin, Geert‐Jan Rutten, Puneet Plaha, Tammie L.S. Benzinger, Asim Mian, Jodie R. Gawryluk, Cyril Pernet, Ōiwi Parker Jones, Sven Haller, Joanna Sierpowska, Ghoufran Talib, Jeffrey R. Binder, Lynne J. Williams, Jorge Jovicich, Michael Zeineh, Manzar Ashtari, Joshua S. Shimony, Monika Połczyńska-Bletsos, Alberto Bizzi, Edward F. Chang, Michael Scheel, Bruce Björnson, Thomas E. Nichols, Christian F. Beckmann, Karsten Geletneky, Susan Y. Bookheimer, Andreas J. Bartsch

Bibliographic record

VenueBrain · 2025
Typearticle
Languageen
FieldMedicine
TopicAdvanced MRI Techniques and Applications
Canadian institutionsBC Children's HospitalUniversity of British ColumbiaUniversity of VictoriaVancouver General Hospital
FundersMedical Research Council
KeywordsClinical PracticeMedical physicsReliability (semiconductor)NeurosurgeryTest (biology)MedicineNeuroscienceClinical decision makingPsychologyIntensive care medicinePhysical therapyPsychiatryBiology

Abstract

fetched live from OpenAlex

Determining the validity and reliability of a test is crucial when the results inform clinical decision-making. Voets et al. highlight priority areas where progress is needed to resolve long-standing controversies surrounding clinical applications of functional MRI in neurosurgery.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.230
metaresearch head score (Gemma)0.340
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: none
Teacher disagreement score0.230
Threshold uncertainty score0.950

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.2300.340
Meta-epidemiology (narrow)0.0030.002
Meta-epidemiology (broad)0.0040.003
Bibliometrics0.0080.004
Science and technology studies0.0040.019
Scholarly communication0.0190.041
Open science0.0100.018
Research integrity0.0260.030
Insufficient payload (model declined to judge)0.0210.011

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.184
GPT teacher head0.457
Teacher spread0.274 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designTheoretical or conceptual
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2025
Admission routes1
Has abstractyes

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