Biliary tract cancers: a descriptive study in the population treated at the Centre Hospitalier Universitaire de Sherbrooke (CHUS) between 2009 and 2021
Bibliographic record
Abstract
Introduction: Biliary tract cancers (BTCs) are associated with a poor prognosis and a lack of standardized management guidelines in Canada, resulting in variable care influenced by age, ethnicity, and region. This study analyzes BTC demographics, diagnostics, treatment modalities, and survival outcomes at the Centre Hospitalier Universitaire de Sherbrooke (CHUS), Quebec. Methods: A retrospective study from 2009 to 2021 included patients aged 18 and older diagnosed with carcinoma-type BTCs and treated at the CHUS. Results: A total of 218 patients were included in our study. The median age at diagnosis was 70.7 years, with 48.6% being male and 51.4% being female. In our population, extrahepatic cholangiocarcinomas were the most frequently diagnosed (31.7%), followed by intrahepatic cholangiocarcinomas (29.8%), gallbladder carcinomas (19.7%), and Ampulla of Vater cancers (16.1%). Identifiable risk factors were very rare. Computed tomography (CT) scans were the primary diagnostic tool (98.1%). Surgical resection was performed in 35.3% of patients, and 40.4% received chemotherapy. The median overall survival was 10.2 months, with a 1-year survival rate of 46%. Patients with Ampulla of Vater cancer had the longest median survival at 55 months. Surgical resection improved overall survival for all biliary tract cancer subtypes, reaching 52 months. Conclusions: BTC patients at CHUS show diverse demographics and cancer types, mirroring national trends. Early detection and surgical treatment enhance survival. Ongoing research is essential to improve BTC management and explore its complex causes.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".