Management of adverse effects after inadvertent intrathecal injection of morphine in a dog undergoing thoracotomy
Bibliographic record
Abstract
A 33-kg adult Labrador Retriever dog presented for investigation of pneumothorax . A computed tomography scan confirmed the diagnosis, and right lateral thoracotomy and lung lobectomy were performed under general anaesthesia. During surgery, anaesthesia was maintained with a propofol constant-rate intravenous (IV) infusion (premedication with methadone and dexmedetomidine) and IV atracurium was given to facilitate surgery. A lumbosacral epidural injection of preservative-free morphine (0.3 mg kg -1 diluted to 6.6 mL with sterile saline) was performed. Using a spinal needle, the ‘hanging drop’ method of detecting the epidural space was attempted but the saline drop was not aspirated, and cerebrospinal fluid entered the needle hub, indicating inadvertent dural puncture. The needle was partially withdrawn and a lack of resistance to injection confirmed before injection of morphine. Following injection, myoclonus of the tail was observed throughout surgery, continuing after atracurium administration. Following surgery, the propofol infusion was reduced from 0.3 to 0.1 mg kg -1 minute -1 to encourage spontaneous ventilation after confirmation of neuromuscular function. Spontaneous ventilation, swallow and palpebral reflexes did not return. The following treatments were unsuccessful in eliciting spontaneous ventilation: allowing end-tidal CO 2 to increase [up to 60 mmHg (8 kPa)], reducing inspired oxygen fraction to 0.4, injection of neostigmine and glycopyrrolate , and stopping propofol delivery. Three doses of butorphanol (each 0.5 mg kg -1 IV) were given 30 minutes apart to antagonize the effects of morphine as it was suspected that inadvertent intrathecal injection had been performed. Butorphanol administration was associated with return of spontaneous ventilation, palpebral and swallow reflexes, and full recovery from anaesthesia. Continuous rate infusions of butorphanol and dexmedetomidine were used for 12 hours to treat any residual respiratory depression and provide sedation to manage continued myoclonus. Myoclonus resolved within 24 hours. The dog was discharged 3 days later and suffered no ongoing adverse effects .
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".