Carnosine-enriched functional food enhances micro- and macrovascular endothelium-independent vasodilation in competitive athletes—a randomized study
Bibliographic record
Abstract
This randomized interventional study aimed to investigate the effect of carnosine-enriched chicken meat consumption on systemic endothelium-dependent and -independent micro- and macrovascular reactivity in thirty-five healthy competitive male athletes. Both forearm skin micro- and macrovascular endothelium-independent vasodilation were increased, and diastolic and mean arterial blood pressure (BP) were decreased in Carnosine group ( n = 19) following the 3-week dietary protocol. Microvascular endothelium-dependent response (post-occlusion reactive hyperemia) was increased in the Carnosine group and significantly associated with decreased mean arterial BP level. Following dietary protocol, Controls ( n = 16) had substantially higher urate (but still normal) levels than the Carnosine group. Carnosine supplementation in the form of functional food enhances endothelium-dependent and vascular smooth muscle-dependent vasodilation in peripheral micro- and microcirculation. Carnosine's effect on vascular endothelium could be attributed to its BP-lowering effect. Results suggest that carnosine has the potential to resist hyperuricemia in healthy individuals. ClinicalTrials.gov (NCT05723939)
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".