Low-dose isotretinoin for the treatment of Morbihan’s disease in a 69-year-old Asian male: A case report
Bibliographic record
Abstract
Morbihan's disease is a rare form of facial lymphedema often associated with chronic rosacea and other skin diseases such as acne. It presents as indurated erythematous plaques in the upper face, which can be challenging to treat. We report a 69-year-old male of Asian background with a 4-year history of facial swelling and redness, unresponsive to prior treatments. After a clinical diagnosis of Morbihan's disease, the patient was treated with oral isotretinoin 10 mg daily, leading to an 80% reduction in symptoms after 9 months. Mild side effects, including cheilitis and xerosis, were well managed. This case highlights low-dose isotretinoin's potential as a therapeutic option for Morbihan's disease. Previous studies have demonstrated the efficacy of treating Morbihan's disease with isotretinoin at high doses between 40 and 80 mg po daily for 12-24 months.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.004 | 0.003 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".