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Record W4407898198 · doi:10.3121/cmr.2024.1945

In-Hospital Management of Acute Trigeminal Neuralgia Pain Crises

2024· article· en· W4407898198 on OpenAlex
Imran Haider, Alexandra Athanaselos, Matthew Patel

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueClinical Medicine & Research · 2024
Typearticle
Languageen
FieldMedicine
TopicTrigeminal Neuralgia and Treatments
Canadian institutionsUniversity of TorontoWilfrid Laurier UniversityQueen's University
Fundersnot available
KeywordsTrigeminal neuralgiaMedicinePain managementAcute painNeuralgiaNeuropathic painAnesthesia

Abstract

fetched live from OpenAlex

Trigeminal neuralgia is the most common form of craniofacial neuropathic pain with an incidence of 4 to 29 per 100,000 people per year. Acute trigeminal neuralgia pain crises are characterized by increased pain frequency and severity and can impact oral intake and sleep, as well as mood. The diagnosis of acute trigeminal neuralgia is clinical and supported by magnetic resonance imaging demonstrating morphological changes in the trigeminal neurovascular bundle on the ipsilateral side of the pain. Patients often present to the hospital seeking relief from acute exacerbations, making it essential for physicians to understand the management of an acute pain crisis, which differs from the chronic management, especially as there may be limited neurology or pain specialist support after hours. The need for improved knowledge of the treatment of acute trigeminal neuralgia is evidenced by opioids being the most prescribed analgesia despite little efficacy in treating it, a lack of evidence supporting their use and concerning side-effects. This article summarizes the evidence behind pharmacological therapy with fosphenytoin, phenytoin, and lidocaine as rescue medications in acute trigeminal neuralgia through the case of a male patient, age 58 years, who experienced complete resolution of pain following administration of phenytoin.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.005
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.587
Threshold uncertainty score0.748

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0050.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0010.001
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.158
GPT teacher head0.541
Teacher spread0.383 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it