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Aseptic loosening is associated with medial tilting and anterior translational migration of the tibial implant in mechanically aligned total knee arthroplasty

2025· article· en· W4407947141 on OpenAlexafffund
Matthew Hickey, Bart L. Kaptein, Carolyn Anglin, Bassam A. Masri, Antony J. Hodgson

Bibliographic record

VenueClinical Biomechanics · 2025
Typearticle
Languageen
FieldMedicine
TopicTotal Knee Arthroplasty Outcomes
Canadian institutionsUniversity of CalgaryUniversity of British Columbia
FundersNatural Sciences and Engineering Research Council of Canada
KeywordsImplantTotal knee arthroplastyMedicineArthroplastyOrthodonticsKnee flexionBiomechanicsSurgeryAnatomy

Abstract

fetched live from OpenAlex

BACKGROUND: Aseptic loosening is a significant cause of implant revision in total knee arthroplasty, and radiostereometric analysis has been used to predict loosening by measuring implant migration over time relative to its position at the time of the index surgery. Studies have suggested that analyzing specific migration patterns may improve prediction of loosening, compared to using measures of the Maximum Total Point Motion alone. Therefore, the objective of this study was to determine whether patients monitored using radiostereometric analysis who experienced either aseptic loosening or revision exhibited distinctive tibial implant migration patterns. METHODS: Extending a previous study using radiostereometric analysis, we calculated the 6-degree-of-freedom tibial implant migration patterns for seven patients with cemented mechanically aligned total knee arthroplasty implants who either developed aseptic loosening or were candidates for revision. We used simple linear regression to identify trends over time. FINDINGS: /month, p < 0.001) and anterior translation (b = 0.67 mm/month, p = 0.005). INTERPRETATION: Our study showed two statistically detectable migration trends associated with tibial component aseptic loosening. Although we were unable to assess in this study whether focusing on migration patterns in these directions provides greater predictive value than using Maximum Total Point Motion, the results suggest that certain migration mechanisms are more prevalent than others, which could motivate further research into the causes of such migration patterns.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.453
Threshold uncertainty score0.560

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.016
GPT teacher head0.297
Teacher spread0.280 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2025
Admission routes2
Has abstractyes

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