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Record W4407947321 · doi:10.1098/rstb.2023.0424

Gas exchange, oxygen transport and metabolism in high-altitude waterfowl

2025· review· en· W4407947321 on OpenAlexafffund
Sabine L. Laguë, Catherine M. Ivy, Julia M. York, Neal J. Dawson, Beverly Chua, Luis Alza, Graham R. Scott, Kevin G. McCracken, William K. Milsom

Bibliographic record

VenuePhilosophical Transactions of the Royal Society B Biological Sciences · 2025
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicHigh Altitude and Hypoxia
Canadian institutionsWestern UniversityMcMaster UniversityBC Children's HospitalUniversity of British Columbia
FundersNatural Sciences and Engineering Research Council of CanadaCanada Research ChairsNational Science Foundation
KeywordsEffects of high altitude on humansHypoxia (environmental)Oxygen transportAltitude (triangle)BiologyEcologyOxygenChemistryAnatomy

Abstract

fetched live from OpenAlex

High-altitude life poses physiological challenges to all animals due to decreased environmental oxygen (O 2 ) availability (hypoxia) and cold. Supporting high metabolic rates and body temperatures with limited O 2 is challenging. Many birds, however, thrive at high altitudes. The O 2 -transport cascade describes the pathway involved in moving O 2 from the environment to the tissues encompassing: (i) ventilation, (ii) pulmonary O 2 diffusion, (iii) circulation, (iv) tissue O 2 diffusion, and (v) mitochondrial O 2 use for ATP production. Shared avian traits such as rigid lungs with cross-current gas exchange and unidirectional airflow aid in O 2 acquisition and transport in all birds. Many high-altitude birds, however, have evolved enhancements to some or all steps in the cascade. In this review, we summarize the current literature on gas exchange and O 2 transport in high-altitude birds, providing an overview of the O 2 -transport cascade that principally draws on the literature from high-altitude waterfowl, the most well-studied group of high-altitude birds. We close by discussing two important avenues for future research: distinguishing between the influences of plasticity and evolution and investigating whether the morphological and physiological differences discussed contribute to enhanced locomotor or thermogenic performance, a potential critical link to fitness. This article is part of the theme issue ‘The biology of the avian respiratory system’.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.004
Threshold uncertainty score0.008

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0010.001
Open science0.0000.000
Research integrity0.0010.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.042
GPT teacher head0.296
Teacher spread0.255 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations3
Published2025
Admission routes2
Has abstractyes

Explore more

Same venuePhilosophical Transactions of the Royal Society B Biological SciencesSame topicHigh Altitude and HypoxiaFrench-language works237,207