Biofunctional Peptide Hydrogel: Self-Assembly, Rheological Properties, and In Vivo Antioxidant Activity of Ovalbumin-Derived Peptide (VLVNAIVFKGL)
Bibliographic record
Abstract
Ovalbumin-derived peptide, VLVNAIVFKGL, demonstrated self-assembling and gelation properties. However, the extent of self-assembly via solvent-switching and the bioactive potential of the ordered peptide aggregates is unknown. In silico analysis using AGGRESCAN, TANGO, ANuPP, and GAP predicted a high propensity to self-assemble into amyloid-like aggregates. Thioflavin T fluorescence assay confirmed enhanced self-assembly at low solvent concentrations (0.03–5% DMSO) and increasing peptide concentration (4–400 μM). Transmission electron microscopy showed enhanced formation of interconnected fibrillar networks at 400 μM. Mechanical properties assessed via rheology confirmed the hydrogelation of the fibrillar networks with high fibrillar stability in simulated gastrointestinal fluids. Oxidative stress assays using Caenorhabditis elegans showed a 21.48 ± 3.37% reduction in juglone-induced reactive oxygen species production by the hydrogel. In silico analysis further predicted the cell-penetrating and nontoxic characteristics of the peptide, highlighting the potential biocompatibility. Taken together, these findings support the development of VLVNAIVFKGL as an antioxidant peptide hydrogel for edible applications.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".