Non-Randomised Placebo-Controlled Trial on Functional Outcome of Intra-Articular Injection of Allogenic Platelet Rich Plasma (PRP) in Patients with Early Osteoarthritis (OA) Knees
Bibliographic record
Abstract
Abstract Background: The advanced stage of knee osteoarthritis (OA) is disabling for the patients; hence, it is essential to control the degenerative process at the earliest. None of the current nonoperative treatment options except platelet-rich plasma (PRP) has been reported to halt the pathology and have more than a short-term relief. After realizing the regenerative potential of the PRP, there have been numerous studies on autologous PRP in OA knee; however, the outcomes have been contradicting among these. Hence, we wanted to evaluate the outcome of allogenic PRP in mild-to-moderate stages of knee OA with active synovitis, which do not respond to other conservative measures of treatment. Methodology: A non-randomized placebo-controlled trial was conducted in a tertiary care hospital between the years 2017 and 2018 for 1 year. We selected both male and female patients with symptomatic bilateral primary OA of knees with symmetrical radiological findings as per Kellgren–Lawrence grading 0–III with a minimum duration of symptoms of 6 weeks who were not responding to oral anti-inflammatory medications and physiotherapy. All the patients were evaluated using Western Ontario and McMaster Universities Arthritis Index (WOMAC) scores before PRP injection, then during follow-ups at 1 month, 3 months, 6 months, 12 months and 18 months post injection. Results: A total of 30 patients were included in this study of which five were males and 25 were females. The median age of OA patients was 60.0 years (Interquartile range = 53.7–66.5 years). We selected patients with bilateral symmetrical Kellegren–Lawrence grading with synovitis phenotype; 6 patients with grade 1 OA, 16 with grade 2 OA, and 9 patients with grade 3 OA. The WOMAC scores for pain and stiffness were significantly higher in the test knees compared to the controls at baseline. In the test knees, both the scores showed a serial reduction till 6 months after the injection. Thereafter, the scores began to gradually worsen. However, at 18 months follow-up the pain score was still significantly lower than the baseline. Conclusion: Allogenic PRP is safe and effective in selected patients with mild-to-moderate OA knee of synovitis/inflammatory phenotype in terms of pain relief and stiffness, especially in the first 6 months post injection. These effects continued till the end of 12 months for stiffness and 18 months for pain.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.003 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.005 | 0.002 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.002 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.003 | 0.002 |
| Insufficient payload (model declined to judge) | 0.008 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".