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Record W4408000680 · doi:10.1177/2050313x251320195

Atypical giant proliferating cystic pilomatrixoma: A case review

2025· review· en· W4408000680 on OpenAlexaff
Kerman Sekhon, Yvette Miller-Monthrope, Christian Murray, Michael J Weinberg

Bibliographic record

VenueSAGE Open Medical Case Reports · 2025
Typereview
Languageen
FieldMedicine
TopicCancer and Skin Lesions
Canadian institutionsTrillium Health CentreWomen's College HospitalUniversity of Toronto
Fundersnot available
KeywordsPilomatrixomaMedicineLesionDermatologyEpitheliomaPresentation (obstetrics)Benign tumorPathologyRadiologyCarcinoma

Abstract

fetched live from OpenAlex

Pilomatrixoma, or calcifying epithelioma of Malherbe, is a rare and benign tumour. Typical presentation of pilomatrixoma is solitary, firm lesions found in the head and neck regions. Pilomatrixoma are often misdiagnosed due to their clinical presentation, which is synonymous with other cutaneous pathology. The reported and true incidence of pilomatrixoma are 1% and 16%, respectively. Cystic pilomatrixoma is a unique variant that presents without the pathognomonic feature of a firm lesion. This study presents the case of a 52-year-old man with a post-auricular pilomatrixoma. It is erythematous, soft, mobile, and 4 cm in diameter. Its size categorizes the lesion as a giant pilomatrixoma. These pilomatrixoma pose a diagnostic challenge as they mimic malignant lesions. It was highly erythematous and mimicked Merkel cell carcinoma in on initial presentation. It was a sebum-filled lesion, which is quite atypical for pilomatrixoma. A previous study finds that only three cases of cystic pilomatrixoma have been reported in the literature previously. This case study presents the case of an atypical variant of a rare tumour. There is a paucity in the literature on cystic pilomatrixoma. Giant proliferating cystic pilomatrixoma has not previously been described in a case report in the literature, as to our knowledge. This study highlights the diversity in the clinical presentations of pilomatrixoma to improve our clinical sensitivity to pilomatrixoma.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.004
metaresearch head score (Gemma)0.016
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Meta-epidemiology (narrow), Insufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Case report · Consensus signal: Case report
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.418
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0040.016
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0060.001
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.001
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0060.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.054
GPT teacher head0.439
Teacher spread0.385 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designCase report
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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