Comparison of intra-articular steroid injection with combined oral steroid and intra-articular steroid injection to treat patients with knee osteoarthritis
Why this work is in the frame
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Bibliographic record
Abstract
Objective: To evaluate the benefits provided by a short course of low dose oral Prednisolone followed by intra-articular injection of Methylprednisolone to treat osteoarthritis Knee as compared to intra-articular injection of Methylprednisolone and placebo. Study Design: Quasi-experimental study Place and Duration of Study: Department of Rehabilitation Medicine, Combined Military Hospital Quetta, Pakistan from Aug to Nov 2023. Methodology: Ninety nine patients with OA of Knee joint were randomly assigned to 3 groups, Group-A received a short course (14 days) of low dose oral steroids (15 mg Prednisolone ) followed by one intra-articular steroid injection (administered two weeks later). Patients in Group-B received intra-articular injection of steroid only and Group-C received intra-articular injection of normal saline. All patients were evaluated using the Western Ontario and McMaster Universities (WOMAC) & Visual Analogue Scale (VAS) score before the treatment and at 2,6,12 and 16 weeks following treatment. Result: There were significant improvements in both Group-A & Group-B. Particularly, patients in Group-A had significantly superior VAS and WOMAC scores than were seen in groups B and C. The VAS and WOMAC scores remained the same as were pre-treatment in group C. Group-A and B both showed improvement but to different extent with superior results in Group-A till 16 weeks. Conclusion: The combination of short course of low dose oral steroids with intra-articular steroid injections resulted in significantly superior symptomatic improvement, with sustained lower VAS and WOMAC scores, hence improving quality of life for 16 weeks.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it