Pericardial Oligometastasis From Merkel Cell Carcinoma Treated With Stereotactic Ablative Radiotherapy
Bibliographic record
Abstract
Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin cancer that often has a poor prognosis due to its propensity for distant metastases. A 74-year-old man with a history of MCC of the left forearm, previously treated with surgery and adjuvant radiotherapy, was found to have an asymptomatic pericardial nodule associated with pericardial effusion on routine follow-up imaging. Subsequent biopsy confirmed metastatic MCC. Restaging demonstrated no other sites of metastases. The pericardial metastasis was treated with stereotactic ablative radiotherapy (SABR) to a dose of 40 Gray (Gy) in five daily fractions. A significant decrease in the size of the pericardial nodule was observed 2.3 months post-SABR, and a clinical complete response was achieved 8.9 months post-SABR. Apart from an asymptomatic mildly increased pericardial effusion, no other acute or late adverse effects were observed. At 40.1 months post-SABR, the patient continued to show a durable response to treatment with no evidence of recurrence. To the best of our knowledge, this case of pericardial oligometastases from MCC treated with SABR is the longest reported duration of response.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".