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Record W4408095678 · doi:10.3389/fpsyg.2025.1303065

AVPR1A RS3 and relationship maintenance processes in newlywed couples

2025· article· en· W4408095678 on OpenAlexaff
Anastasia Makhanova, James K. McNulty, Lisa A. Eckel, Larissa Nikonova, Jennifer A. Bartz, Arial Bloshinsky, Elizabeth A. D. Hammock

Bibliographic record

VenueFrontiers in Psychology · 2025
Typearticle
Languageen
FieldPsychology
TopicNeuroendocrine regulation and behavior
Canadian institutionsMcGill University
Fundersnot available
KeywordsPsychologyAlleleExtant taxonDevelopmental psychologySocial psychologyGeneticsGeneEvolutionary biologyBiology

Abstract

fetched live from OpenAlex

Introduction Maintaining relationship quality during the first few years can be difficult for many couples. We examined whether variability in the repeat-length polymorphism RS3 on the vasopressin receptor gene AVPR1A is associated with relationship maintenance processes and trajectories of marital satisfaction over the first three years of marriage. Methods Newlywed couples (N=70; 128 individuals) reported on various aspects of their marriage within three months of their wedding and on their marital satisfaction every four months for three years, and provided saliva samples that we genotyped for RS3 alleles. Based on the literature, we predicted that people with at least one copy of target allele 334 (vs. none) would report more problems in pair bonding. We also used another genotype analysis approach from the extant literature, by testing whether people with a greater (vs. fewer) number of short alleles would report more problems in pair bonding. Results Across both approaches, results failed to support our predictions. In fact, the significant effects that did emerge were in the opposite direction from our predictions: people with at least one copy of allele 334 reported fewer marital problems and less interest in romantic alternatives; the number of short alleles was similarly positively associated with more dedication to the relationship and greater relationship satisfaction at the beginning of marriage. Discussion Discrepancies between these findings and prior research illustrate the challenges of candidate gene studies with small sample sizes. Nevertheless, in offering a potential reconciliation between the discrepancies, we suggest that attending to relational phase may be critical to understanding the role of RS3 in couple functioning; AVPR1A RS3 variability may be differentially associated with pair bonding in the newlywed stage compared to established marriages.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.003
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.003
Threshold uncertainty score0.008

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.003
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0010.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.027
GPT teacher head0.360
Teacher spread0.333 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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