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Record W4408158553 · doi:10.1200/cci-24-00143

Using a Longformer Large Language Model for Segmenting Unstructured Cancer Pathology Reports

2025· article· en· W4408158553 on OpenAlexaff
Gregory Arbour, Kaitlin Muzio, Raymond T. Ng

Bibliographic record

VenueJCO Clinical Cancer Informatics · 2025
Typearticle
Languageen
FieldComputer Science
TopicTopic Modeling
Canadian institutionsUniversity of WaterlooUniversity of British Columbia
Fundersnot available
KeywordsPathologyMarket segmentationComputer scienceNatural language processingMedicineArtificial intelligenceBusiness

Abstract

fetched live from OpenAlex

PURPOSE: Many Natural Language Processing (NLP) methods achieve greater performance when the input text is preprocessed to remove extraneous or unnecessary text. A technique known as text segmentation can facilitate this step by isolating key sections from a document. Give that transformer models-such as Bidirectional Encoder Representations from Transformers (BERT)-have demonstrated state-of-the-art performance on many NLP tasks, it is desirable to leverage such models for segmentation. However, transformer models are typically limited to only 512 input tokens and are not well suited for lengthy documents such as cancer pathology reports. The Longformer is a modified transformer model designed to intake longer documents while retaining the positive characteristics of standard transformers. This study presents a Longformer model fine-tuned for cancer pathology report segmentation. METHODS: We fine-tuned a Longformer Question-Answer (QA) model on 504 manually annotated pathology reports to isolate sections such as diagnosis, addenda, and clinical history. We compared baseline methods including regular expressions (regex) and BERT QA. However, those methods may fail to correctly identify section boundaries. Model performance was evaluated using sequence recall, precision, and F1 score. RESULTS: Final test results were obtained on a hold-out test set of 304 cancer pathology reports. We report sequence F1 scores for the following sections: diagnosis (0.77), addenda (0.48), clinical history (0.89), and overall (0.68). CONCLUSION: We present a fine-tuned Longformer model to isolate key sections from cancer pathology reports for downstream analyses. Our model performs segmentation with greater accuracy.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.005
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Simulation or modeling · Consensus signal: Simulation or modeling
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.018
Threshold uncertainty score0.036

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.005
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.001
Science and technology studies0.0000.001
Scholarly communication0.0010.003
Open science0.0020.001
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0040.003

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.094
GPT teacher head0.446
Teacher spread0.352 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designSimulation or modeling
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2025
Admission routes1
Has abstractyes

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