Increased alkaline phosphatase associated with brown algae and mushroom extract–containing supplement use
Bibliographic record
Abstract
Background: Marked alkaline phosphatase (ALP) elevation as a consequence of drug exposure is uncommon. We report a chronic hepatitis B virus (HBV) positive 47-year-old male patient taking a brown algae and mushroom extract-containing supplement (Umi No Shizuku) with ALP levels almost 7 times the upper limit during routine bloodwork. ALP was 991 U/L (normal 50-112 U/L). All other liver studies were within normal range: alanine aminotransferase (ALT) 32 U/L (normal 10-63 U/L), aspartate aminotransferase (AST) 25 U/L (normal 12-41 U/L), gamma-glutamyl transferase (GGT) 22 U/L (normal 11-105 U/L), and total bilirubin 13 µmol/L (normal ≤ 13 µmol/L). Methods: Serial bloodwork was conducted to assess liver studies and bone disease markers. Imaging was utilized to exclude liver and bone disease. Results: Bloodwork and imaging all returned values within the normal range. Interrupting the supplement led to rapid normalization of ALP blood levels in the patient. Conclusions: The supplement was the only variable changed in this case, leading us to suspect that it was responsible for the elevated ALP levels.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".