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Record W4408177824 · doi:10.1016/j.semperi.2025.152062

NIPPV vs CPAP: Lessons from meta-analyses

2025· review· en· W4408177824 on OpenAlexaff
Marc‐Olivier Deguise, Brigitte Lemyre

Bibliographic record

VenueSeminars in Perinatology · 2025
Typereview
Languageen
FieldMedicine
TopicCongenital Heart Disease Studies
Canadian institutionsOttawa HospitalChildren's Hospital of Eastern Ontario
Fundersnot available
KeywordsMedicineMeta-analysisInternal medicine

Abstract

fetched live from OpenAlex

Care of the extremely premature infant has been in constant state of re-evaluation as the population, technologies and knowledge continue to evolve. A growing population of extremely low gestational age neonates (ELGAN - <28 weeks) and "nanopremies" (<24 weeks) are undergoing successful resuscitation, stabilization, and intensive care leading to improved survival. Respiratory care is the cornerstone of ELGAN management, as their lungs are at a critical stage of development. The lifesaving intensive care they require can lead to various injurious stimuli making them prone to bronchopulmonary dysplasia (BPD). Non-invasive ventilation (NIV), including continuous positive airway pressure ventilation (CPAP) and nasal intermittent positive pressure ventilation (NIPPV) has evolved and can appropriately support premature infants' breathing, while limiting the invasiveness and associated complications of mechanical ventilation. This review focuses on our current understanding, knowledge and evidence gathered via meta-analysis on these two modes of NIV in preterm infants, when used either as primary intent respiratory support post-birth or following extubation. We will summarize the current data of recent meta-analyses, their pitfalls, and the remaining questions to be addressed by future research to optimize the use of these modes of respiratory support in preterm infants most at risk for BPD.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.002
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Insufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Other design · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.958
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.002
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0080.002
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0050.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.207
GPT teacher head0.493
Teacher spread0.286 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designOther design
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations4
Published2025
Admission routes1
Has abstractyes

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