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Record W4408216368 · doi:10.1101/2025.03.06.25323508

Physical activity predicts fitness and walking capacity after stroke: a diagnostic accuracy study

2025· preprint· en· W4408216368 on OpenAlexafffund
Kevin Moncion, Lynden Rodrigues, Bernat de las Heras, Elise Wiley, Kenneth S. Noguchi, Janice J. Eng, Ada Tang, Marc Roig

Bibliographic record

VenuemedRxiv · 2025
Typepreprint
Languageen
FieldMedicine
TopicStroke Rehabilitation and Recovery
Canadian institutionsMcMaster UniversityVancouver Coastal HealthUniversity of British Columbia, Okanagan CampusKelowna General HospitalUniversity of British ColumbiaMcGill UniversityJewish Rehabilitation Hospital
FundersMichael Smith Health Research BCCanadian Institutes of Health ResearchPhysiotherapy Foundation of CanadaMitacsCanada Research ChairsHeart and Stroke Foundation of Canada
KeywordsPhysical medicine and rehabilitationStroke (engine)Diagnostic accuracyPhysical fitnessPhysical activityPhysical therapyPsychologyMedicineEngineeringInternal medicine

Abstract

fetched live from OpenAlex

Abstract Background and Purpose Clinicians need access to accurate self-reported tools that can assist with screening individuals who are at risk for fitness (V̇O 2 peak) and walking impairments (e.g., 6-minute walk test [6MWT] distance) post-stroke. The associations and diagnostic metrics between self-reported physical activity as measured by the Physical Activity Scale for People with Disabilities (PASIPD, MET-hours/week) and V̇O 2 peak (≥ 15 mL/kg/min) and 6MWT (≥ 350 m) among ≥ 6 months post-stroke were evaluated. Methods This is a secondary analysis from an aerobic exercise RCT. Participants’ age, sex, V̇O 2 peak, 6MWT distance and the PASIPD were collected at baseline. Multivariable logistic regression analyses evaluated the association between V̇O 2 peak (≥ 15 mL/kg/min), 6MWT (≥ 350 m) and the PASIPD (MET-hours/week). Predicted classifications and the Youden index identified cut points of the PASIPD. Results Eighty-five participants (n=53 males, aged 65.1 ± 9.5 years, 1.8 ± 1.2 years post-stroke) were included. Significant associations were found whereby one-unit increase in the PASIPD (MET-hours/week) was associated with a 21% increase in the odds of having a V̇O 2 peak ≥ 15 mL/kg/min [aOR = 1.21; 95% CI 1.07, 1.36, p=0.002] and 14% increase in the odds of having a 6MWT ≥ 350 m [aOR = 1.14; 95% CI 1.05, 1.23, p=0.001] with excellent area under the curve values (AUC: 0.82-0.93). Youden-derived PASIPD cut points of 8.9 and 10.6 MET-hours/week may identify individuals with fitness (≥ 15 mL/kg/min) and walking impairments (≥ 350 m)post-stroke (AUC: 0.69-0.71). Discussion and Conclusions Clinicians may use the self-reported PASIPD to identify individuals with fitness and walking impairments post-stroke.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.005
metaresearch head score (Gemma)0.022
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.005
Threshold uncertainty score0.027

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0050.022
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0020.002
Science and technology studies0.0010.001
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.023
GPT teacher head0.311
Teacher spread0.288 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes2
Has abstractyes

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