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“Brain Wellness in Comiziano”: Epidemiological Study on Potential Protective Factors for Alzheimer’s Disease in a Small Italian Village

2025· preprint· en· W4408217836 on OpenAlexaboutno aff
Cinzia Coppola, Deborah Archetto, Elisabetta Signoriello, Rosario Cisonni, Gianmarco Abbadessa, Simona Bonavita, Pasquale Alfieri

Bibliographic record

VenuePreprints.org · 2025
Typepreprint
Languageen
FieldMedicine
TopicDementia and Cognitive Impairment Research
Canadian institutionsnot available
Fundersnot available
KeywordsEpidemiologyDiseaseAlzheimer's diseaseMedicineEnvironmental healthGerontologyPsychiatryPsychologyPathology

Abstract

fetched live from OpenAlex

The aging of the population and, consequently, dementias represent a priority for global public health. This door-to-door epidemiological study was conducted in a small agricultural community with no migratory flows in the past few decades in Campania. The aim was to identify lifestyles that may be either favourable to the development of dementia. A total of 206 participants were recruited from 502 individuals aged 60 and over. The residents were assessed using the Montreal Cognitive Assessment (MoCA) and Cognitive Reserve Index questionnaire. Regarding the factors associated with cognitive decline, there was a statistically significant association between older age and impairment in MoCA scores. Additionally, a statistically significant association was found between altered MoCA scores and weight loss over the past six months (p < 0.048). A statistically significant association was found between altered MoCA scores and the perception of cognitive deficit (p < 0.029). In conclusion, in our homogeneous community, a low prevalence of cognitive decline was observed, with cognitive reserve playing an important protective role, while advanced age, weight loss, and subjective cognitive deficit were identified as risk factors. Additionally, a low prevalence of cognitive deficits emerged, which may be associated with the habits and lifestyle of the inhabitants.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.021
Threshold uncertainty score0.041

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0010.000
Scholarly communication0.0010.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.203
GPT teacher head0.430
Teacher spread0.227 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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Same venuePreprints.org→Same topicDementia and Cognitive Impairment Research→French-language works237,207→