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The COVID-19 pandemic's effects on cognition and 24-hour movement behaviours: Findings from the CLSA

2025· article· en· W4408313425 on OpenAlexafffundabout
Ryan S. Falck, Megan E. O’Connell, Vanessa Taler, Parminder Raina, Christina Wolfson, Lauren E. Griffith, Eric E. Smith, Teresa Liu‐Ambrose

Bibliographic record

VenueMaturitas · 2025
Typearticle
Languageen
FieldPsychology
TopicCOVID-19 and Mental Health
Canadian institutionsUniversity of CalgaryMcMaster UniversityVancouver Coastal HealthBruyèreMcGill University Health CentreUniversity of Saskatchewan
FundersCanadian Institutes of Health ResearchCanada Foundation for InnovationGovernment of CanadaWeston Family FoundationUniversité de SherbrookeMcMaster UniversityUniversity of Ottawa
KeywordsMedicineCoronavirus disease 2019 (COVID-19)Pandemic2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)CognitionVirologyInternal medicinePsychiatryOutbreakInfectious disease (medical specialty)Disease

Abstract

fetched live from OpenAlex

BACKGROUND: The COVID-19 pandemic may have negatively impacted cognition due to pandemic-associated changes in 24-h movement behaviours (i.e., physical activity, sedentary behaviour, and sleep). Whether the pandemic's effects vary by age and sex is unclear. METHODS: We examined those participants (aged 45-85 years) of the Canadian Longitudinal Study on Aging (CLSA) with complete neuropsychological measures at baseline (2011-2015), no dementia/memory disorder, and partial or complete assessments at baseline, 3-year (FU1; 2015-2018), and 6-year follow-up (FU2; 2018-2021). Participants were categorized into pre-pandemic (N = 6174) or intra-pandemic (N = 5181) cohorts by FU2 assessment timing (before/after March 11th, 2020) and stratified by baseline age/sex. Cognition was measured with reliable change indices using: the Rey Auditory-Verbal Learning Test, Mental Alternation Test (MAT), and animal fluency. We indexed physical activity and sedentary behaviour using the Physical Activity Scale for the Elderly (PASE), and self-reported restless sleep. FINDINGS: Compared with their pre-pandemic peers, intra-pandemic men aged 65-85 years had lower animal fluency (-0.40 points, 99 % CI: [-0.72, -0.07]), lower PASE (-16.48 points, 99 % CI: [-24.60, -8.36]) and 14 % higher probability of ≥4 h/day sedentary behaviour (99 % CI: [0.03, 0.26]) at FU2. Intra-pandemic women aged 65-85 years had lower MAT (-0.43 points, 99 % CI: [-0.86, -0.01]) and 12 % higher probability of ≥4 h/day sedentary behaviour (99 % CI: [0.01, 0.23]). There were no between-cohort differences for those aged 45-64 years. Pandemic-related changes in 24-h movement behaviours (FU1 to FU2) were not associated with cognitive changes, regardless of age or sex. INTERPRETATION: The pandemic's effects on cognition and 24-h movement behaviours varied by age and sex; these effects are unrelated.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.252
Threshold uncertainty score0.419

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0010.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.054
GPT teacher head0.397
Teacher spread0.344 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations3
Published2025
Admission routes3
Has abstractyes

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