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Ethics in Patient Preferences for Artificial Intelligence–Drafted Responses to Electronic Messages

2025· article· en· W4408330332 on OpenAlexaff
Joanna S Cavalier, Benjamin A. Goldstein, Vardit Ravitsky, Jean‐Christophe Bélisle‐Pipon, Armando Bedoya, Sam Klotman, Matthew Roman, Jessica Sperling, Chun Xu, Eric G. Poon, Anand Chowdhury

Bibliographic record

VenueJAMA Network Open · 2025
Typearticle
Languageen
FieldMedicine
TopicArtificial Intelligence in Healthcare and Education
Canadian institutionsSimon Fraser University
Fundersnot available
KeywordsLikert scaleSeriousnessFamily medicineMedicineScale (ratio)Patient satisfactionHealth careTest (biology)PsychologyNursing

Abstract

fetched live from OpenAlex

Importance: The rise of patient messages sent to clinicians via a patient portal has directly led to physician burnout and dissatisfaction, prompting uptake of artificial intelligence (AI) to alleviate this burden. It is important to understand patient preferences around AI in patient-clinician communication as ethical guidelines on appropriate use and disclosure (patient notification of AI use) are developed. Objective: To analyze patient preferences regarding use of AI in electronic messages. Design, Setting, and Participants: A survey study was conducted within the Duke University Health System's patient advisory committee, consisting of individuals 18 years or older who participate in periodic surveys to inform health system patient care practices. Multiple surveys were administered to test the impact of different factors, including response author, disclosure (AI, human, or none), and seriousness of the topic. A follow-up survey assessed preferred disclosure verbiage. Surveys were administered from October 31 to December 11, 2023. Exposure: Multiple surveys. Main Outcomes and Measures: Participants rated their overall satisfaction, usefulness of the information, and perceived level of care on a 5-point Likert scale. Results: Of the 2511 members surveyed, 1455 (57.9%) responded, with respondents being older (median age, 57 [IQR, 49-70] vs 53 [IQR, 41-62] years), more educated (872 of 1083 [80.5%] vs 319 of 440 [72.5%] with a college or graduate degree), and predominantly female (921 [63.3%]). Participants preferred AI- compared with human-drafted responses, with a mean difference for satisfaction of -0.30 (95% CI, -0.37 to -0.23) points, usefulness of -0.28 (95% CI, -0.34 to -0.22) points, and perception they were cared for of -0.43 (95% CI, -0.50 to -0.37) points. Participants tended to have higher satisfaction with a human disclosure over AI disclosure, with a mean difference of 0.13 (95% CI, 0.05-0.22) points, and with no disclosure over AI authorship disclosure, with a mean difference of 0.09 (95% CI, 0.01-0.17) points. Regardless of author or disclosure type, more than 75% of respondents were satisfied (agree or strongly agree) with the response. Conclusions and Relevance: In this survey study, participants expressed a mild preference for messages written by AI but had a slightly decreased satisfaction when told AI was involved. Patient experience must be considered along with ethical implementation of AI. Although AI disclosure may slightly reduce satisfaction, disclosure should be maintained to uphold patient autonomy and empowerment.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.003
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Other design · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.889
Threshold uncertainty score0.556

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0020.003
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.238
GPT teacher head0.489
Teacher spread0.251 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designOther design
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations35
Published2025
Admission routes1
Has abstractyes

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