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Record W4408367900 · doi:10.1177/08903344251320587

About Research: Clinical Versus Statistical Significance

2025· article· en· W4408367900 on OpenAlexaff
Kathryn Wouk, Kathleen S. Kenny, Ellen Chetwynd

Bibliographic record

VenueJournal of Human Lactation · 2025
Typearticle
Languageen
FieldMedicine
TopicBreastfeeding Practices and Influences
Canadian institutionsUniversity of ManitobaManitoba Health
Fundersnot available
KeywordsStatistical significanceMedicinePsychologyStatisticsMathematics

Abstract

fetched live from OpenAlex

Research plays a critical role in advancing evidence-based practice by providing measurable insights into the relationships between exposures or interventions and outcomes. These insights are often constructed through the application of statistical research findings to inform clinical care. The significance of a research finding is not determined by its statistically significant effect estimates or p values alone. For research outcomes to be clinically significant and effectively guide evidence-based practice, they must be evaluated in light of several characteristics: their magnitude (i.e., size of the effect estimates), precision (i.e., range of values within which we think the true effect estimate lies), consistency (i.e., alignment with existing literature), and clinical applicability to the target population (i.e., relevance to informing practice for populations of interest).

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.003
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.747
Threshold uncertainty score0.313

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0020.003
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.253
GPT teacher head0.555
Teacher spread0.301 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2025
Admission routes1
Has abstractno

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