Moldable and Particulate Bone Material in Alveolar Ridge Preservation: A Multicenter Randomized Controlled Trial
Bibliographic record
Abstract
INTRODUCTION: This study aimed to determine possible histological and radiological differences in alveolar ridge preservation (ARP), using moldable bone versus particulate bone. METHODS: After tooth extraction, 39 patients (40 teeth) were randomized (1:1) to receive ARP using moldable bone materials (SBX group) or particulate bone materials (PBX group). An absorbable collagen membrane was placed over the graft material and the surgical site was sutured. Cone-beam computed tomography was taken immediately and 5 months after ARP. Bone core samples from the implantation site were obtained for histomorphometric analysis 5 months after ARP. RESULTS: Forty-six patients were screened and 39 of them completed the study. However, one patient who received split-mouth treatment was excluded, resulting in data from 38 patients being analyzed. In radiological evaluation, the changes in midbuccal alveolar bone height at 5 months were -0.753 ± 0.112 and -1.018 ± 0.111 mm in the SBX group and PBX groups, respectively (F = 2.895; p = 0.098; mean difference [MD] 0.265; 95% confidence interval [CI] = -0.051 to 0.582). Changes in the horizontal ridge width were measured at three levels (-1, -3, and -5 mm) below the most coronal aspect of the crest and showed a decrease in both groups, with no significant differences between the groups. The percent new bone area of the SBX group (39.156 ± 2.505) was significantly different from that of the PBX group (22.749 ± 2.476) (F = 22.171; p < 0.001; 95% MD 16.407; CI = 9.333 to 23.481). The percent residual material area was significantly lower in the SBX group (8.973 ± 2.211) compared to the PBX group (15.633 ± 2.186), with an F-statistic of 4.687 and p-value = 0.037 (MD -6.660; 95% CI = -12.904 to -0.415). The percent connective tissue area was 49.743 ± 4.199 and 56.657 ± 4.151 for the groups (F = 1.401; p = 0.245; MD -6.914; 95% CI = -18.773 to 4.944), respectively. CONCLUSION: Radiological and histological results showed that use of moldable bone can achieve similar ARP parameters as those achieved by particulate bone. TRIAL REGISTRATION: Clinical Research Information Service No. KCT0009560. This randomized clinical trial was not registered before participant recruitment and randomization. (Date of registration: 21/06/2024. https://cris.nih.go.kr/cris/search/detailSearch.do?seq=27272&searchpage=L).
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.003 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.004 | 0.002 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.006 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".