Diastolic Function and Left Atrial Mechanics in Children With Marfan and Loeys-Dietz Syndrome
Bibliographic record
Abstract
Background: Diastolic function in patients with pediatric Marfan syndrome (MFS) and Loeys-Dietz syndrome (LDS) remains underexplored. Conventional diastolic assessments in this population can be challenging, and speckle-tracking echocardiography (STE)-derived left atrial (LA) strain measurements offer a novel and sensitive approach. Methods: This retrospective, observational study included 37 patients with MFS, 37 patients with LDS, and 30 age-matched controls. Comprehensive echocardiographic evaluations were performed to assess diastolic function. STE-based LA strain measurements during the reservoir, conduit, and pump phases were obtained and analyzed. Results: = 0.004). LA pump strain remained similar between groups. In addition, conventional diastolic parameters differed significantly between MFS, LDS, and controls. Conclusions: Pediatric patients with MFS and LDS exhibit lower LA reservoir and conduit strains, along with differences in early diastolic parameters, while maintaining preserved LA pump function. These findings suggest subclinical changes in early diastolic function. STE-derived LA strain offers a sensitive, noninvasive method for detecting subtle functional impairments that may precede clinical dysfunction, underscoring its diagnostic potential for early monitoring and management of at-risk patients.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".