Quantitative ultrasound and photoacoustic assessments of red blood cell aggregation in the human radial artery
Why this work is in the frame
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Bibliographic record
Abstract
We develop concurrent US and photoacoustic (PA) imaging to characterize structural/physiological impact of in-vivo red blood cell (RBC) aggregation. PA images at 700/800/900 nm were collected from the radial arteries of 12 participants across age groups (20 s/30 s/40 s) alongside US images (21 MHz, VevoLAZR). RBC aggregate size was estimated from US-derived structure-factor-size-estimation ( D SFSE ) and PA-derived spectral-slope (SS), along with oxygen saturation (sO 2 ). At peak systole (PS), D SFSE PS and SS PS approximated 1 RBC and −0.1 dB/MHz, respectively, across all ages, with sO 2 PS values of 97.1 %, 94.7 %, and 93.0 % for each group. At end diastole (ED), D SFSE ED , SS ED and sO 2 ED values were 2.6, 3.4, and 4.7 RBCs; −0.7, −0.9, and −1.2 dB/MHz; and 98.7 %, 97.2 %, and 96.7 %, respectively. Differences between SS ED and SS PS (δSS) and sO 2 ED and sO 2 PS (δsO 2 ) increased with age, indicating aging-related increases in DSFSE and δSS, as well as decreases in sO 2 PS and sO 2 ED .
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it