Case Report: Glioneuronal Hamartoma in the Cerebral Cortex of a Juvenile Cynomolgus Monkey ( <i>Macaca fascicularis</i> )
Bibliographic record
Abstract
Two dark and raised foci were observed on the left hemisphere of the brain of a 3-year-old cynomolgus monkey during the routine necropsy procedures of a preclinical toxicity study. Microscopic examination revealed a lesion in the cerebral cortex at the junction of the parietal and occipital lobes, consisting of disorganized, but generally well-circumscribed collections of mixed glial and neuronal cells within a fibrillar stroma. Numerous eosinophilic granular bodies, brown pigment-laden macrophages, and lymphocytic infiltrates were also noted. Immunohistochemical staining for glial fibrillary acidic protein, neurofilament, and Ki-67, as well as histochemical stains Masson's Trichrome and Klüver-Barrera confirmed the presence of both glial and neuronal cells within a collagenous stroma, without significant proliferation. Both histopathological and immuno/histochemical stains were consistent with a glioneuronal hamartoma. This report describes the first case of such a lesion in a nonhuman primate.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".