Novel Phenoselenazines as Amyloid-β Aggregation Inhibitors
Bibliographic record
Abstract
A novel library of N -benzylphenoselenazine derivatives 8a – j were designed, synthesized, and evaluated as inhibitors of amyloid-beta (Aβ42) aggregation. In the thioflavin T-based fluorescence aggregation kinetics assay, compounds 8i and 8j exhibited excellent inhibition of Aβ42 aggregation (∼91% inhibition at 25 μM), and the activity was comparable to that of reference agents resveratrol (∼88%) and methylene blue (∼95% inhibition). Both compounds also demonstrated Aβ42 disaggregation properties (58% and 76% respectively at 25 μM) and antioxidant activity (80.5% and 59% respectively at 25 μM). In the cell culture studies, both 8i and 8j were able to reduce Aβ42-mediated cytotoxicity. Computational studies suggest that these compounds interact in a narrow channel formed by the N- and C-termini in the Aβ42 pentamer model to stabilize the assembly and prevent further aggregation. These results demonstrate the viability of the N -benzylphenoselenazines as promising candidates to target the amyloid cascade in Alzheimer’s disease.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".