Effects of FlexProMD<sup>®</sup>, a Mixture of Krill Oil, Astaxanthin, and Hyaluronate, on Symptoms in Subjects With Mild Knee Osteoarthritis
Bibliographic record
Abstract
This study aimed to evaluate the efficacy of the dietary supplement FlexProMD , which consists of krill oil, astaxanthin, and hyaluronic acid, in subjects with Kellgren-Lawrence (KL) grade 1 or lower, for whom the risk of side effects from pharmacological treatment is high.Of the 105 applicants, 21 met the KL grade I criteria or lower and were randomly assigned into two groups: 11 participants to the FlexProMD group, and 10 participants to the placebo group.Each group received either a FlexProMD capsule (600 mg) or a placebo capsule (600 mg), administered once daily for 12 weeks in a double-blind manner.Treatment efficacy was assessed at weeks 0, 6, and 12 using the Korean Visual Analog Scale (K-VAS) to evaluate pain levels and the Korean Western Ontario and McMaster Universities Osteoarthritis Index (K-WOMAC) to assess pain, joint stiffness, physical function and the three in total.The reduction in K-VAS scores from the baseline in the FlexProMD group was significant at both week 6 (P = 0.043) and week 12 (P = 0.008), indicating that this food exhibited pain-relieving activity.Moreover, this effect was proportional to the duration of administration.However, the placebo group showed no reduction at both observation weeks.The total K-WOMAC score, which evaluates overall joint function, showed a significant reduction in the FlexProMD group at week 6 compared to the placebo group (P = 0.043).However, at week 12, the reduction was not statistically significant (P = 0.099).The pain score in the FlexProMD group was significantly reduced at week 6 compared to the placebo group (P = 0.029) and remained reduced at week 12, though this reduction was not statistically significant.The physical function scores in the FlexProMD group decreased at both week 6 and week 12 but were not statistically significant (P = 0.099 and P = 0.051, respectively).No effects on stiffness were observed.The lack of effects on physical function and stiffness was attributed to the absence or mildness of symptoms in participants with KL grade I or lower.FlexProMD demonstrated alleviating effects in individuals with KL grade I or lower osteoarthritis, suggesting that it may be a useful health functional food for managing borderline or subclinical patients who do not require pharmacological treatment.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".