Randomised, double-blind, placebo-controlled study to evaluate the effect on human strength and endurance after resistance training and supplementation of <i>Vicia faba</i> protein hydrolysate compared with placebo
Bibliographic record
Abstract
Objective To assess the effects of a Vicia faba protein hydrolysate (VFH) on muscular strength and endurance when combined with resistance training for 56 days compared with exercise alone in a mixed population. Design A double-blind placebo-controlled parallel trial. Participants 72 healthy men and women aged 19–40, stratified in a 1:1 ratio by gender. Participants were excluded if they performed >3 hours of resistance training per week in the 6 months prior. Setting Ontario, Canada. Study performed by KGK Science from August 2023 to January 2024. Intervention VFH or silica microcrystalline cellulose is given in five capsules daily for 56 days. Main outcome measures Primary outcome: Leg strength via one-repetition maximum for bilateral leg extension. Secondary outcomes: Muscular endurance via repetitions to exhaustion, body composition via dual-energy X-ray absorptiometry, plasma biomarkers via ELISA, quality of life via short form survey (SF-36) questionnaire. Results Intergroup analysis revealed a significantly greater increase in leg strength compared with placebo at day 28 (p=0.045) and 56 (p=0.05), respectively. Significantly enhanced muscular endurance was also observed from days 0 to 56 with a difference of 2.2 times in the change in repetitions performed from baseline (p=0.022) and a 21.6% increase compared with the placebo. Significant changes in bone mineral content were reported between groups (p=0.032) with a mean increase of 0.7% gained in the VFH group. The improvements in performance were supported by myokine analysis where VFH was shown to modulate a range of biomarkers associated with glucose homeostasis, bone formation, mitochondrial and metabolic function. Quantitative physical strength gains were consistent with qualitative data which showed significantly improved changes in self-assessed health. Conclusions VFH supplementation demonstrated significant improvements in muscular strength, endurance and bone mineral content when compared with placebo. These low-dose, peptide-induced improvements enhance the effects of exercise for musculoskeletal health and have the potential to influence all-cause mortality via muscular strength. Trial registration number NCT05946746 .
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".