Mausolate Complexes of the Alkaline Earth Metals
Bibliographic record
Abstract
The capacious and rigid mausolate ligand [1]2- has the capacity to adaptively coordinate some of the largest metal cations on the periodic table, such as those which are utilized in targeted alpha-particle therapy. One such ion, Ra2+, has proven challenging to keep securely contained by other chelators. Here we investigate the binding behaviour of the Ba2+ (96% the size of Ra2+ but conveniently non-radioactive) with the mausolate [1]2- along with the other alkaline earth metals Mg2+, Ca2+, and Sr2+, principally utilizing real time electrospray ionization mass spectrometry monitoring. We also report the syntheses of several functionalized mausolate derivatives, [3-5]2-, and compare their binding abilities with previously reported variants. We find that the mausolates display a distinct preference for larger alkaline earth metals, with Ba2+ showing extremely rapid uptake and promising stability in a number of physiologically relevant conditions. The incorporation of a reactive bromine atom in the 4-pyridine position of the mausolate ([3]2-) can be utilized to introduce further functionalization through a nucleophilic substitution pathway without compromising coordination ability.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".