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Record W4408957000 · doi:10.1093/jamia/ocaf051

<u>A</u> I- <u>T</u> echniques <u>L</u> oss-Based <u>A</u> lgorithm for <u>S</u> everity Classification (ATLAS): a novel approach for continuous quantification of exertional symptoms during incremental exercise testing

2025· article· en· W4408957000 on OpenAlexafffund
Sophia Wang, Danilo Cortozi Berton, Igor Neder‐Serafini, Sandra G. Vincent, Matthew D. James, Nicolle J. Domnik, Devin B. Phillips, Luíz Eduardo Nery, Denis E. O’Donnell, J. Alberto Neder

Bibliographic record

VenueJournal of the American Medical Informatics Association · 2025
Typearticle
Languageen
FieldMedicine
TopicChronic Obstructive Pulmonary Disease (COPD) Research
Canadian institutionsYork UniversityQueen's University
FundersSoutheastern Ontario Academic Medical OrganizationQueen's University
KeywordsAtlas (anatomy)HumanitiesPhysicsMedicineArtAnatomy

Abstract

fetched live from OpenAlex

OBJECTIVE: Heightened muscular effort and breathlessness (dyspnea) are disabling sensory experiences. We sought to improve the current approach of assessing these symptoms only at the maximal effort to new paradigms based on their continuous quantification throughout cardiopulmonary exercise testing (CPET). MATERIALS AND METHODS: After establishing sex- and age-adjusted reference centiles (0-10 Borg scale), we developed a novel algorithm (AI-Techniques Loss-Based Algorithm for Severity Classification [ATLAS]) based on reciprocal exponential loss for CPET data from patients with chronic obstructive lung disease of varied severity. RESULTS: Categories of dyspnea intensity by ATLAS-but not dyspnea at peak exercise-correctly discriminated patients in progressively higher resting and exercise impairment (P < .05). DISCUSSION: This new AI-techniques approach will be translated to the care of disabled patients to uncover the seeds and consequences of their activity-related symptoms. CONCLUSIONS: We used innovative informatics research to change paradigms in displaying, quantifying, and analyzing effort-related symptoms in patient populations.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.006
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.483
Threshold uncertainty score0.727

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0030.006
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.024
GPT teacher head0.328
Teacher spread0.304 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations3
Published2025
Admission routes2
Has abstractyes

Explore more

Same venueJournal of the American Medical Informatics AssociationSame topicChronic Obstructive Pulmonary Disease (COPD) ResearchFrench-language works237,207