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Record W4409148098 · doi:10.1002/clt2.70043

Radiological score, asthma and NSAID‐exacerbated respiratory disease predict relapsing chronic rhinosinusitis

2025· article· en· W4409148098 on OpenAlex
Markus Lilja, Anni Koskinen, Sari Hammarén‐Malmi, Anu Laulajainen‐Hongisto, Jura Numminen, Jyri Myller, Seija Vento, Elina Penttilä, Maija Hytönen, Paula Virkkula, Peter W. Hellings, Sven Seys, Heini Huhtala, Johanna Sahlman, Sanna Toppila‐Salmi

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueClinical and Translational Allergy · 2025
Typearticle
Languageen
FieldMedicine
TopicSinusitis and nasal conditions
Canadian institutionsUniversity of TorontoSt. Michael's Hospital
FundersFilhaTampereen TuberkuloosisäätiöJane ja Aatos Erkon SäätiöYrjö Jahnssonin SäätiöTaysVäinö ja Laina Kiven SäätiöSuomen Lääketieteen Säätiö
KeywordsMedicineChronic rhinosinusitisAsthmaRadiological weaponSinus (botany)SinusitisProportional hazards modelNasal polypsRespiratory systemConcha bullosaHazard ratioInternal medicineSurgeryRadiologyConfidence interval

Abstract

fetched live from OpenAlex

OBJECTIVES: The aim was to evaluate the predictive potential of Sinonasal Radiological (SR) and the Lund-Mackay (LM) score of sinus computed tomography (CT) scans on postoperative relapses of chronic rhinosinusitis (CRS). MATERIALS AND METHODS: CRS patients (n = 483, 12-80 years) underwent routine sinus CT scans. The SR score was defined by obstructed frontal recess (0 = no, 1 = yes) and visualization of middle and inferior turbinate (0 = anatomy can be easily visualized, 1 = anatomy cannot be easily visualized) on each side (a total of 0-6 points). Associations were analyzed by nonparametric, survival and Cox's proportional hazard models. RESULTS: Revision endoscopic sinus surgery (ESS) was performed in 133 (28.0%) patients on average (min-max) of 3.2 (0-12) years after performing the sinus CT scans. Of the 408 patients who underwent the baseline ESS, high preoperative SR or LM scores significantly predicted revision ESS (p < 0.001) and peroral corticosteroid courses purchased during the follow-up (p = 0.009 and p < 0.001, respectively for SR- and LM-scores). In multivariable analysis, both SR score and asthma and/or NSAID exacerbated respiratory disease (N-ERD) were significantly associated with revision ESS risk (p = 0.035, p = 0.007, respectively). CONCLUSION: LM and SR and a history of asthma or N-ERD predict CRS relapses, which may help in decision-making.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.096
Threshold uncertainty score0.502

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.040
GPT teacher head0.331
Teacher spread0.291 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it