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Record W4409181783 · doi:10.1016/j.lana.2025.101083

Biases inherent in all-cause mortality studies: implications for shaping the 2025–2030 dietary guidelines for Americans on alcohol consumption

2025· article· en· W4409181783 on OpenAlexaff
Kevin D. Shield, Katherine M. Keyes, Priscilla Martínez, Adam J. Milam, Jürgen Rehm, Timothy S. Naimi

Bibliographic record

VenueThe Lancet Regional Health - Americas · 2025
Typearticle
Languageen
FieldMedicine
TopicAlcohol Consumption and Health Effects
Canadian institutionsCanadian Institute for Advanced ResearchUniversity of TorontoCentre for Addiction and Mental HealthWestern University
Fundersnot available
KeywordsEnvironmental healthAlcohol consumptionConsumption (sociology)MedicineAlcoholSociologySocial scienceBiology

Abstract

fetched live from OpenAlex

Alcohol is an addictive substance that has both detrimental and protective health outcomes at low doses.1 The net impact of alcohol on health at low doses depends on the underlying risks of diseases and injuries causally linked to alcohol and thus varies across countries. As such, informing the public about the health risks of alcohol consumption requires country-specific information. The Review of Evidence on Alcohol and Health by the National Academies of Sciences, Engineering, and Medicine (NASEM) aims to inform the 2025–2030 Dietary Guidelines for Americans.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Direct model labels (unvalidated)

Per-model category and study-design labels from the labeling rounds. They are machine output, unvalidated, and the disagreement between models ships as data. No study design here is MEDLINE-validated yet.

Model armCategoriesStudy designConfidence
gptMetaresearch
Domain: Methods · Genre: Commentary
About the Canadian research system: yes · About a Canadian topic: yes
Theoretical or conceptuallow
grokMetaresearch
Domain: Methods · Genre: Commentary
About the Canadian research system: no · About a Canadian topic: no
Theoretical or conceptualmedium
opusMetaresearch
Domain: Methods · Genre: Commentary
About the Canadian research system: no · About a Canadian topic: no
Not applicablemedium
models splitAgreement compares identical category sets and study designs across arms.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Commentary · Consensus signal: Commentary
Teacher disagreement score0.668
Threshold uncertainty score0.602

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0010.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.921
GPT teacher head0.661
Teacher spread0.260 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Labeled directly by 3 models reading the full record.

Metaresearch

The models disagree on parts of this classification; every voice is preserved in the section at the end of the page.

Study designTheoretical or conceptual · Not applicable
DomainMethods
GenreCommentary

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2025
Admission routes1
Has abstractyes

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