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Vitamin E nomenclature

2025· review· en· W4409225168 on OpenAlexafffund
Angelo Azzi, Jeffrey Atkinson, Nesrin Kartal Özer, Danny Manor, Maria Wallert, Francesco Galli

Bibliographic record

VenueFree Radical Biology and Medicine · 2025
Typereview
Languageen
FieldNursing
TopicVitamin C and Antioxidants Research
Canadian institutionsBrock University
FundersHorizon 2020Natural Sciences and Engineering Research Council of CanadaNational Institutes of HealthMinistero dell’Istruzione, dell’Università e della RicercaEuropean Commission
KeywordsNomenclatureMedicineChemistryBiologyZoologyTaxonomy (biology)

Abstract

fetched live from OpenAlex

The 3rd Vitamin E Satellite Symposium (VESS3) "100 years of vitamin E", held in 2022 during the joint meeting of the Society for Free Radical Research (SFRR)-Europe branch and the Plant Oxygen Group (POG), was an occasion to reunite the scientific community interested in vitamin E and debate on its fundamentals in human nutrition one century after its discovery. This conference initiated a discussion forum dedicated to the revision of the nomenclature of vitamin E that was hosted in this journal (https://www.sciencedirect.com/special-issue/10GWS76VWXX). The forum collected 8 papers, including the opening article "Vitamin E discussion forum - position paper on the revision of the nomenclature of vitamin E"(Azzi, Atkinson et al., 2023), that addressed the nomenclature issue essentially suggesting "to restrict to RRR-α-tocopherol the attribute of vitamin E″ and to identify "… other related molecules, including chroman-6-ols (i.e. non-α-tocopherols and tocotrienols) and chromen-6-ols by their chemical names until a disease is identified that is prevented by the specific compounds.". The articles published in this forum issue are summarized and their final considerations critically evaluated. The consensus to have come out of these articles favors the original revision proposal, with the modification of including all 2R stereoisomers of α-tocopherol (α-TOH), in addition to RRR-α-TOH (natural form), in the definition of vitamin E. Further and more rigorous studies on the molecular and clinical aspects of vitamin E essentiality were also advised together with studies on the essentiality of other vitamin E-related compounds.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.007
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: none
Teacher disagreement score0.025
Threshold uncertainty score0.083

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0030.007
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0090.007
Science and technology studies0.0020.003
Scholarly communication0.0060.004
Open science0.0020.003
Research integrity0.0030.004
Insufficient payload (model declined to judge)0.0250.023

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.034
GPT teacher head0.403
Teacher spread0.369 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations4
Published2025
Admission routes2
Has abstractyes

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