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Record W4409237671 · doi:10.1038/s41537-025-00572-7

Bridging Science and Hope: integrating and Communicating Lived experience in Accelerating Medicines Partnership® Schizophrenia Program

2025· article· en· W4409237671 on OpenAlex
Ameneh Asgari-Targhi, Beier Yao, Lisa Brown, S. Sánchez García, Arundati Nagendra, Tashrif Billah, Nora Penzel, Omar John, Nicholas Prunier, Simone Veale, Elana Kotler, Grace R. Jacobs, Ming Zhan, Michael Coleman, Sylvain Bouix, Ofer Pasternak, Guillermo Cecchi, Justin T. Baker, Daniel H. Mathalon, Sinéad Kelly, Cheryl M. Corcoran, Abraham Reichenberg, Inge Winter-van Rossum, Marek Kubicki, Jessica Spark, Dominic Dwyer, Celso Arango, Paolo Fusar‐Poli, Monica E. Calkins, Jai Shah, Vijay A. Mittal, Andrew Thompson, Patrick D. McGorry, René S. Kahn, John M. Kane, Carrie E. Bearden, Scott W. Woods, Barnaby Nelson, Martha E. Shenton, Brandon Staglin, Carlos A. Larrauri, Kathryn E. Lewandowski, Tina Kapur

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueSchizophrenia · 2025
Typearticle
Languageen
FieldArts and Humanities
TopicMental Health and Psychiatry
Canadian institutionsMcGill UniversityDouglas CollegeÉcole de Technologie Supérieure
FundersNational Institutes of HealthWellcome TrustWellcomeNational Institute of Mental HealthU.S. Department of Health and Human Services
KeywordsBridging (networking)General partnershipSchizophrenia (object-oriented programming)PsychologyMedical educationPsychotherapistPsychiatryMedicineComputer sciencePolitical scienceComputer security

Abstract

fetched live from OpenAlex

The Accelerating Medicines Partnership Schizophrenia (AMP® SCZ) program integrates lived experience into psychosis research, leveraging over three decades of foundational studies to improve research quality, promote community engagement, and ensure ethical implementation of precision psychiatry. Lived experience is embedded in the program’s governance, shaping study protocols, recruitment strategies, and digital tools such as the mindLAMP platform. Study sites also integrate lived experience through youth advisory boards, peer support specialists, and advisory committees, ensuring diverse perspectives inform research design and implementation. These efforts aim to develop predictive tools and therapeutic strategies while maintaining ethical and participant-centered practices. Advocacy organizations, such as the National Alliance on Mental Illness (NAMI), have fostered collaboration among government, industry, and academic partners, shaping outreach and engagement strategies. Dissemination efforts, led by the Website and Outreach Workgroup (WOW), include an accessible, Section 508-compliant website and co-designed resources, building trust and engagement within communities. By integrating lived experience at every stage, the program aims to foster trust, enhance research outcomes, and inform future strategies for treatment and prevention. Watch Dr. Tina Kapur, Dr. Kathryn Eve Lewandowski, and Dr. Carlos A. Larrauri discuss this article and their work at: https://vimeo.com/1050068801 .

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesScience and technology studies
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Other design · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.735
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0020.001
Scholarly communication0.0010.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.073
GPT teacher head0.355
Teacher spread0.282 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it