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Record W4409295349 · doi:10.3389/fbinf.2025.1585717

A cost and community perspective on the barriers to microbiome data reuse

2025· article· en· W4409295349 on OpenAlexaff
Julia M. Kelliher, L. Johnson, Francisca E. Rodriguez, Jaclyn K. Saunders, Marie Kroeger, Buck Hanson, Aaron Robinson, Winston Anthony, Marc W. Van Goethem, E. Anders Kiledal, Ahmed A. Shibl, Cassandra L. Ettinger, Chhedi Lal Gupta, Chris R. P. Robinson, Cristal Zúñiga, Daniel D. Sprockett, Douglas Terra Machado, Emilie J. Skoog, Iyanu Oduwole, Jason A. Rothman, Kaelan Prime, Katherine R. Lane, Leandro Nascimento Lemos, Lisa Karstens, Mark McCauley, Mitiku Mihiret Seyoum, Moamen M. Elmassry, Mustafa Güzel, Reid Longley, Simon Roux, Thomas M. Pitot, Emiley A. Eloe‐Fadrosh

Bibliographic record

VenueFrontiers in Bioinformatics · 2025
Typearticle
Languageen
FieldComputer Science
TopicResearch Data Management Practices
Canadian institutionsUniversité LavalUniversity of Calgary
FundersPacific Northwest National LaboratoryBiological and Environmental ResearchLos Alamos National LaboratoryLawrence Berkeley National LaboratoryOffice of ScienceU.S. Department of Energy
KeywordsPerspective (graphical)ReuseMicrobiomeData scienceSociologyKnowledge managementManagement scienceEngineering ethicsComputer scienceEngineeringEcologyBiologyBioinformaticsArtificial intelligence

Abstract

fetched live from OpenAlex

Microbiome research is becoming a mature field with a wealth of data amassed from diverse ecosystems, yet the ability to fully leverage multi-omics data for reuse remains challenging. To provide a view into researchers' behavior and attitudes towards data reuse, we surveyed over 700 microbiome researchers to evaluate data sharing and reuse challenges. We found that many researchers are impeded by difficulties with metadata records, challenges with processing and bioinformatics, and problems with data repository submissions. We also explored the cost constraints of data reuse at each step of the data reuse process to better understand "pain points" and to provide a more quantitative perspective from sixteen active researchers. The bioinformatics and data processing step was estimated to be the most time consuming, which aligns with some of the most frequently reported challenges from the community survey. From these two approaches, we present evidence-based recommendations for how to address data sharing and reuse challenges with concrete actions for future work.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.270
metaresearch head score (Gemma)0.528
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Open science
Consensus categoriesMetaresearch
DomainCandidate signal: Reproducibility · Consensus signal: none
Study designCandidate signal: Qualitative · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.994
Threshold uncertainty score0.900

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.2700.528
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0090.016
Science and technology studies0.0080.012
Scholarly communication0.0210.025
Open science0.0060.018
Research integrity0.0040.005
Insufficient payload (model declined to judge)0.0060.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.093
GPT teacher head0.364
Teacher spread0.271 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; the direct Gemma label and the distilled Codex classifier agree on what is shown here.

Study designQualitative
DomainReproducibility
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations4
Published2025
Admission routes1
Has abstractyes

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