Self-related thought alterations associated with intrinsic brain dysfunction in mild cognitive impairment
Bibliographic record
Abstract
The subjective experience of self-awareness is attributed to the human capacity for introspective thought during periods of mind-wandering. However, how this cognitive function is impacted in individuals with mild cognitive impairment (MCI) still needs to be better understood. To address this gap, we investigated alterations in self-referential thinking in a cohort of 30 MCI patients, comparing them to 60 healthy old-aged and 60 healthy younger controls. MCI patients exhibited a notable decline in overall cognitive function, as evidenced by significantly lower scores on the Montreal Cognitive Assessment (MoCA), with particular deficits in Memory subscore and Memory Index Score (MIS). Employing the Amsterdam Resting-State Questionnaire (ARSQ) to assess mind-wandering, we observed diminished self-related thoughts relating to personal past experiences and future thinking among MCI patients. Notably, using high-density electroencephalography (hdEEG) microstate analysis, we detected reduced neural activity for microstate C associated with self-related thoughts in MCI patients and healthy older relative to healthy younger controls, and an increase in neural activity for microstate A in MCI patients compared to healthy older and younger controls. This aberrant temporal activity was localized within brain regions implicated in episodic autobiographical memory and the default mode network. Our results highlight a link between impaired mind-wandering ability and dysfunction within the intrinsic neural networks of MCI patients, underscoring its implications for disruptions in the sense of self within this clinical population.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.002 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".