Neuroprotection as a way to rehabilitate patients after haemorrhagic fever with renal syndrome
Bibliographic record
Abstract
The objective of the study was to evaluate the efficacy of Citoflavin in the correction of mild cognitive disorders detected in the process of dispensary observation in patients who had undergone a moderate form of HFRS. Patients and methods. We conducted a comprehensive examination of 50 patients who had undergone a moderately severe form of HFRS with laboratory confirmation and were discharged from the infectious hospital, in whom mild cognitive disorders were detected as part of the postinfection syndrome in the course of medical examination. The patients were randomised into 2 groups of 25 patients each. The patients of the main group received intravenous infusions of Cytoflavin (CF) for 10 days at a dose of 10 ml per 100 ml of 0.9% sodium chloride solution, the comparison group – ‘active placebo’ (100.0 ml of 0.9% sodium chloride solution). During the examination, the patients were questioned using the Montreal Cognitive Assessment Scale (MoCA test) and SF-36 questionnaire before and after 10 days of neuroprotective therapy. Results. In the dynamics of observation, patients in the main group in comparison with the placebo group showed significant differences in the number of complaints about dizziness, headache, decreased mental performance, sleep disorders; in the MoCA-test a higher total score was recorded against the background of increased level of cognitive functions; according to the results of the SF-36 questionnaire a significant improvement in the quality of life was registered due to physical functioning and condition, pain intensity, general condition, vital activity and mental indices. The tolerability of Cytoflavin in all patients was good, no side effects were observed. Conclusion. Cytoflavin in the complex treatment of patients with mild cognitive impairment as part of the postinfection syndrome who have suffered from moderately severe forms of HFRS allows to reduce neurological deficit and contributes to the restoration of neurocognitive functions. Key words: hemorrhagic fever with renal syndrome, neuroprotection, Cytoflavin
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".