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Record W4409371019 · doi:10.1038/s42003-025-07963-7

The FinnBrain multimodal neonatal template and atlas collection

2025· article· en· W4409371019 on OpenAlexafffund
Jetro J. Tuulari, Aylin Rosberg, Elmo P. Pulli, Niloofar Hashempour, Elena Ukharova, Kristian Lidauer, Ashmeet Jolly, Silja Luotonen, Hilyatushalihah K. Audah, Elena Vartiainen, Wajiha Bano, Ilkka Suuronen, Isabella Lucia Chiara Mariani Wigley, Vladimir Fonov, D. Louis Collins, Harri Merisaari, Linnéa Karlsson, Hasse Karlsson, John D. Lewis

Bibliographic record

VenueCommunications Biology · 2025
Typearticle
Languageen
FieldComputer Science
TopicSpeech and dialogue systems
Canadian institutionsMental Health Research CanadaHospital for Sick ChildrenMontreal Neurological Institute and Hospital
FundersTurun Yliopistollinen KeskussairaalaTurun YliopistoHospital for Sick ChildrenAalto-YliopistoSickkids Research InstituteMcGill University
KeywordsAtlas (anatomy)Computer scienceMedicineAnatomy

Abstract

fetched live from OpenAlex

The accurate processing of neonatal and infant brain MRI data is crucial for developmental neuroscience but presents unique challenges that child and adult data do not. Tissue segmentation and image coregistration accuracy can be improved by optimizing template images and related segmentation procedures. Here, we describe the construction of the FinnBrain Neonate (FBN-125) template, a multi-contrast template with T1- and T2-weighted, as well as diffusion tensor imaging-derived fractional anisotropy and mean diffusivity images. The template is symmetric, aligned to the Talairach-like MNI-152 template, and has high spatial resolution (0.5 mm³). Additionally, we provide atlas labels, constructed from manual segmentations, for cortical grey matter, white matter, cerebrospinal fluid, brainstem, cerebellum as well as the bilateral hippocampi, amygdalae, caudate nuclei, putamina, globi pallidi, and thalami. This multi-contrast template and labelled atlases aim to advance developmental neuroscience by achieving reliable means for spatial normalization and measures of neonate brain structure via automated computational methods. We also provide standard volumetric and surface co-registration files to enable investigators to transform their statistical maps to the adult MNI space, improving the consistency and comparability of neonatal studies or the use of adult MNI space atlases in neonatal neuroimaging.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.946
Threshold uncertainty score0.575

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0010.000
Scholarly communication0.0000.000
Open science0.0010.001
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.017
GPT teacher head0.294
Teacher spread0.276 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations3
Published2025
Admission routes2
Has abstractyes

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