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Record W4409417639 · doi:10.1016/s1470-2045(25)00150-0

Using patient-reported outcomes and health-related quality of life data in regulatory decisions on cancer treatment: highlights from an EMA-EORTC workshop

2025· article· en· W4409417639 on OpenAlexaff
Madeline Pe, Caroline Voltz-Girolt, Jill A. Bell, Vishal Bhatnagar, Jan Bogaerts, Christopher Booth, Juan García Burgos, Joseph C. Cappelleri, Corneel Coens, Pierre Démolis, Harald Enzmann, Johannes M. Giesinger, Alexandra Gilbert, Mogens Grøenvold, Paul G. Kluetz, Claire Piccinin, Douwe Postmus, Chantal Quinten, Bettina Ryll, Maxime Sasseville, Michael Schlichting, Hans Schuerer, Anja Schiel, James W. Shaw, Ashley Wilder Smith, Shun Tezuka, Carla Torre, Winette T.A. van der Graaf, Beate Wieseler, Friedrich Wittenbecher, Jaap C. Reijneveld, Peter G. M. Mol

Bibliographic record

VenueThe Lancet Oncology · 2025
Typearticle
Languageen
FieldEconomics, Econometrics and Finance
TopicHealth Systems, Economic Evaluations, Quality of Life
Canadian institutionsHealth CanadaQueen's University
FundersPTC TherapeuticsPfizerMerck KGaAEli Lilly and CompanyBristol-Myers Squibb
KeywordsQuality of life (healthcare)CancerMedicineQuality (philosophy)GerontologyInternal medicineNursing

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.261
metaresearch head score (Gemma)0.354
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesMetaresearch
DomainCandidate signal: Evaluation · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.739
Threshold uncertainty score0.911

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.2610.354
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0030.004
Bibliometrics0.0040.009
Science and technology studies0.0010.005
Scholarly communication0.0170.017
Open science0.0050.006
Research integrity0.0100.019
Insufficient payload (model declined to judge)0.0030.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.734
GPT teacher head0.561
Teacher spread0.173 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; the direct Gemma label and the distilled Codex classifier agree on what is shown here.

Study designNot applicable
DomainEvaluation
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations22
Published2025
Admission routes1
Has abstractno

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Same venueThe Lancet OncologySame topicHealth Systems, Economic Evaluations, Quality of LifeFrench-language works237,207