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Record W4409425199 · doi:10.1101/2025.04.10.25325555

Agreeability testing of AMSTAR-PF, a tool for quality appraisal of systematic reviews of prognostic factor studies

2025· preprint· en· W4409425199 on OpenAlexaff
Henry Michael, Neil E O’Connell, Richard D Riley, Karel G.M. Moons, Beverley Shea, Lotty Hooft, Sarah B. Wallwork, Johanna AAG Damen, Nicole Skoetz, Ruth Appiah, Carolyn Berryman, S. Crouch, Grace Ferencz, Ashley Grant, Katherine Henry, Aleksandra M. Herman, Emma L. Karran, Indika Koralegedera, Hayley B. Leake, Erin MacIntyre, Brendan Mouatt, Karma Phuentsho, Daniel Van Der Laan, Ellana Welsby, Louise Wiles, Erica Wilkinson, Megan Wilson, Monique V. Wilson, G. Lorimer Moseley

Bibliographic record

VenuemedRxiv · 2025
Typepreprint
Languageen
FieldMedicine
TopicHealthcare Systems and Public Health
Canadian institutionsUniversity of Ottawa
Fundersnot available
KeywordsSystematic reviewQuality (philosophy)Computer scienceBiologyMEDLINEPhilosophyEpistemology

Abstract

fetched live from OpenAlex

Abstract Background This paper details initial testing of the agreeability and usability of a novel quality appraisal tool for systematic reviews of prognostic factor studies: AMSTAR-PF. Methods Fourteen appraisers each assessed eight systematic reviews using AMSTAR-PF. Their ratings for each question and each article were compared, with interrater, inter-pair and intrapair agreeability calculated using Gwet’s agreement coefficient. Time of use and time to reach consensus were also recorded. Results Interrater agreement averaged 0.59 (range, 0.21-0.90), inter-pair 0.61 (range 0.24-0.91) and intrapair 0.75 (range 0.45-0.95) across the domains, with agreement for the overall rating 0.46 (95%CI 0.30-0.62) for interrater, 0.46 (95%CI 0.17-0.74) for inter-pair, and 0.68 (range of averages 0.22-1.00) for intrapair agreement. The majority (60.7%) of intrapair ratings were identical, with 94.6% of final ratings either identical or only one category different for the overall appraisal. The time taken to appraise a study with AMSTAR-PF improved with use and averaged around 34 minutes after the first two appraisals. Conclusions Despite some variance in agreeability for different domains and between different appraisers, the testing results suggest that AMSTAR-PF has clear utility for appraising the quality of systematic reviews of prognostic factor studies.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.672
metaresearch head score (Gemma)0.870
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesMetaresearch
DomainCandidate signal: Evaluation · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.328
Threshold uncertainty score0.404

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.6720.870
Meta-epidemiology (narrow)0.0020.002
Meta-epidemiology (broad)0.0050.016
Bibliometrics0.0180.015
Science and technology studies0.0030.005
Scholarly communication0.0060.008
Open science0.0030.010
Research integrity0.0030.004
Insufficient payload (model declined to judge)0.0040.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.414
GPT teacher head0.515
Teacher spread0.101 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; the direct Gemma label and the distilled Codex classifier agree on what is shown here.

Study designObservational
DomainEvaluation
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2025
Admission routes1
Has abstractyes

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