The impact of autologous platelet rich plasma in the prevention of hypertrophic scar on the site of sternotomy: a pilot clinical trial
Bibliographic record
Abstract
Background: Platelet-rich plasma (PRP) has shown a good effect in healing different types of wounds in the studies. This study was conducted with the aim of investigating the impact of Autologous PRP in the prevention of hypertrophic scar on the site of sternotomy in adults. Methods: This pilot clinical trial study was conducted on 28 patients undergoing open heart surgery. Before the surgery and the injection of anesthetic drugs, a certain volume of blood was taken from the patient through the CVP line by the anesthesiologist, and the PRP solution was prepared with the help of a standard kit. The hypertrophic scars were evaluated by the Vancouver Scar Scale (VSS) at 2, 12 and 24 weeks after surgery. Data analysis was done by SPSS version 16 software. P < 0.05 was considered significant. Results: The GEE test, comparing the VSS score between the intervention group and the control group over time shows that there is no significant difference between the intervention and control groups ( P > 0.05). This means that the lower part of the CABG surgical incision, where the PRP was injected, showed no significant difference in the incidence of hypertrophic scars compared to the upper part, considered as control group during the investigation. Conclusion: PRP injection cannot be effective on the scar of the sternotomy surgical site in patients. Since this study was conducted as a pilot, it is suggested to conduct a study with a large sample size in line with the purpose of this study.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".