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Record W4409476002 · doi:10.2337/dc25-0096

Influence of Maternal Glycemia on Breast Milk Composition and Volume Ingested by Infants of Mothers With Type 1 Diabetes

2025· article· en· W4409476002 on OpenAlexafffund
Lois Donovan, Rhonda C. Bell, Jennifer M. Yamamoto, Patricia Lemieux, Josephine Ho, Denice S. Feig, Heidi Virtanen, Susan Crawford, Raylene A. Reimer

Bibliographic record

VenueDiabetes Care · 2025
Typearticle
Languageen
FieldMedicine
TopicBreastfeeding Practices and Influences
Canadian institutionsAlberta HealthAlberta Health ServicesSinai Health SystemUniversity of TorontoUniversity of ManitobaUniversité LavalManitoba HealthUniversity of CalgaryLunenfeld-Tanenbaum Research InstituteMount Sinai HospitalCentre hospitalier de l'Université LavalChildren's Hospital Research Institute of ManitobaAlberta Children's HospitalUniversity of Alberta
FundersCalgary Health FoundationDexcomNovo NordiskTandem Diabetes CareSanofi
KeywordsMedicineBreast milkLactoseBreastfeedingBreast feedingType 1 diabetesEndocrinologyInternal medicineDiabetes mellitusFructoseFood scienceBiologyBiochemistryPediatrics

Abstract

fetched live from OpenAlex

OBJECTIVE: To examine relationships between maternal glucose and breast milk composition and volume ingested by infants of mothers with type 1 diabetes (T1D), and to compare breast milk composition in women with and without T1D. RESEARCH DESIGN AND METHODS: Midfeed breast milk samples were collected from 11 mothers with T1D. Maternal continuous glucose monitoring data were correlated with breast milk composition and volume ingested. Breast milk composition was compared between the women with T1D and five without T1D. RESULTS: Forty-seven breast milk samples from mothers with T1D were analyzed. Maternal glucose 90-120 min before breastfeeding correlated with breast milk glucose and fructose but not with lactose, protein, fatty acids, leptin, or volume consumed. Breast milk leptin correlated with volume of breast milk consumed (r = 0.394; P = 0.008). Higher breast milk glucose (1.0 ± 0.3 vs. 0.7 ± 0.3 mg/mL) and leptin (463.6 ± 480.0 vs. 114.4 ± 68.6 pg/mL) were found in women with versus without T1D. CONCLUSIONS: Maternal glucose is associated with breast milk glucose and fructose in women with T1D but not with volume of breast milk consumed.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.004
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.003
Threshold uncertainty score0.006

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.004
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.004
GPT teacher head0.233
Teacher spread0.229 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2025
Admission routes2
Has abstractyes

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