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Record W4409482223 · doi:10.1186/s12886-025-04036-5

Clinicopathological correlation of caruncular lesions: a 22-year report from the Middle East

2025· article· en· W4409482223 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueBMC Ophthalmology · 2025
Typearticle
Languageen
FieldMedicine
TopicOcular Oncology and Treatments
Canadian institutionsUniversity of Toronto
Fundersnot available
KeywordsMedicineCorrelationOptometry

Abstract

fetched live from OpenAlex

INTRODUCTION: Caruncular lesions are uncommon and diverse, making accurate clinical diagnosis challenging. Discrepancies between clinical and histopathological diagnoses are frequent, and malignant lesions can metastasize early. The lack of substantial regional data necessitates a detailed study of the clinical and histopathological characteristics of these lesions. METHODS: A retrospective study was conducted over a 22-year period, including 52 patients with caruncular lesions. Clinical presentations, demographic data, and histopathological findings were recorded. All lesions underwent biopsy and histological examination to correlate clinical and pathological diagnoses. RESULTS: A total of 52 patients with caruncular lesions were included, with a mean age of 48 years. The majority presented with unilateral lesions, and six patients had bilateral involvement. The most common presenting complaints were pigmented or enlarging masses. Histopathological examination revealed 13 distinct lesion types, with inflammatory lesions (25%) and melanocytic tumors (23%) being the most common. Malignant lesions were identified in 11.5% of cases. The clinicopathological correlation was accurate in 23% of cases. CONCLUSION: Caruncular lesions present significant diagnostic challenges due to their rarity and histopathological diversity. This study underscores the importance of histopathological examination for accurate diagnosis and highlights the need for regional data to better understand the epidemiology of these lesions. The findings also suggest that while most lesions are benign, a high index of suspicion for malignancy should be maintained, particularly in cases of rapid growth or atypical presentation.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.006
Threshold uncertainty score0.382

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.103
GPT teacher head0.361
Teacher spread0.258 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it