Abstract P3055: Longitudinal Associations of Dairy Derived Serum Fatty Acids with Early Type 2 Diabetes Mellitus Risk Phenotypes: Findings from the Prospective Metabolism and Islet cell Evaluation (PROMISE) Cohort
Bibliographic record
Abstract
Background: Evidence suggests that dairy-derived saturated and trans fatty acids may contribute to observed inverse associations of dairy intake with risk of metabolically associated fatty liver disease (MAFLD) and type 2 diabetes mellitus (T2DM). Longitudinal studies examining the association between circulating dairy fatty acids and phenotypes underlying these disorders are limited. This study aimed to investigate the 9-year longitudinal associations of 15:0 (pentadecanoic acid), t16:1n9 (trans palmitoleic acid), t18:1n11 (trans vaccenic acid) and c9,t11 CLA (conjugated linoleic acid) in four serum fractions with insulin sensitivity, beta cell function and alanine aminotransferase (ALT in U/L, a biomarker of liver function). Methods: In the PROMISE cohort (n=460), insulin sensitivity was assessed using Matsuda’s insulin sensitivity index (ISI) and the homeostasis model assessment of insulin sensitivity (HOMA2_S). Beta cell function was determined using the insulinogenic index divided by HOMA insulin resistance (IGI/IR) and the Insulin Secretion-Sensitivity Index-2 (ISSI-2). Serum ALT was measured at each visit. Baseline serum fatty acids (mol%) in the cholesteryl ester (CE), non-esterified fatty acid (NEFA), phospholipid (PL) and triglyceride (TG) pools were analyzed using gas chromatography flame-ionization detection. Longitudinal associations were analyzed using covariate-adjusted generalized estimating equations with P values adjusted using the Benjamini-Hochberg False Discovery Rate (FDR). Results: In the TG pool, 18:1n11t was significantly associated with logISSI-2 (β= 3.09, CI: [0.04, 6.24], p<0.05). Significant inverse associations were observed between 15:0 (CE) and logALT (β= -3.30, CI: [-5.33, -1.24], p<0.01). In the PL pool, 15:0 was positively associated with logISSI-2 (β=5.37, CI: [1.71, 9.16], p<0.01) and logIGI/IR (β=10.49, CI: [4.35, 16.99], p<0.01). After FDR adjustment, 15:0 (CE) continued to be inversely associated with logALT (p<0.05). Similarly, 15:0 (PL) was significantly associated with logISSI-2 and logIGI/IR (p<0.05). Fatty acids in the NEFA and TG pools were not significantly associated with outcomes. Conclusions: Longitudinal associations of dairy-derived serum fatty acids with liver health and beta cell function were detected across serum pools. Our findings expand the literature on the potential role of dairy-derived saturated and trans conjugate fatty acids in cardiometabolic phenotypes underlying MAFLD and T2DM.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".