Cytokine response to resistance exercise in children with excess adiposity and Prader‐Willi syndrome
Bibliographic record
Abstract
Interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), and irisin (cytokines) are affected by excess body fat (obesity), skeletal muscle, and resistance exercise (RE). The purpose of this study is to determine whether Prader-Willi Syndrome (PWS), a genetic cause for obesity (OB), or non-syndromic OB influences these cytokine responses to RE. Nine children with PWS (11.4 ± 3.3 years, 45.6 ± 5.2% BF), 11 children without OB (9.2 ± 1.4 years, 18.6 ± 5.0% BF), and 12 children with OB (9.6 ± 1.3 years, 40.4 ± 5.4% BF) participated. Children stepped onto an elevated platform wearing a weighted vest for 6 sets of 10 repetitions per leg separated by 1 min of rest. Blood samples were obtained before exercise (pre), immediately post (IP), and during recovery (+15 and +60 min). There were no group-by-time interactions for any cytokine; and neither time nor group effects for TNF-α or irisin (p ≥ 0.378). For IL-6, 60+ was higher than pre, IP, and +15 (p < 0.001). Children with PWS and OB had increased IL-6 than children without OB (p ≤ 0.038). Neither PWS nor OB affected IL-6, TNF-α or irisin responses to RE. However, excess body fat was associated with higher IL-6 concentrations.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".