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Record W4409651604 · doi:10.1002/cap.10360

Soft tissue grafting in healing chronic wounds: Two case studies

2025· article· en· W4409651604 on OpenAlexaff
Francisco J. Otero‐Cagide, Oscar Rodríguez‐Estévez

Bibliographic record

VenueClinical Advances in Periodontics · 2025
Typearticle
Languageen
FieldMedicine
TopicPeriodontal Regeneration and Treatments
Canadian institutionsUniversity of Saskatchewan
Fundersnot available
KeywordsMedicineWound healingSoft tissueEnamel matrix derivativeChronic woundSurgeryWound closureSkin graftingDentistryChronic periodontitisRegeneration (biology)Periodontitis

Abstract

fetched live from OpenAlex

BACKGROUND: A chronic wound occurs when it fails to heal resulting in a prolonged wound healing process. Traumatic and surgically induced wounds that do not heal as expected can be included in the term chronic wound. There is limited information about the management of this type of wound involving the periodontal tissues. These case studies show how soft tissue grafting may be used as a strategy to assist in the closure and enhancement of large wounds that present a chronic and complicated healing process. METHODS AND RESULTS: Two healthy adult patients presented open wounds induced by trauma following the dental treatment. These wounds were treated with autogenous soft tissue grafting to enhance and stimulate the healing process. In one case, enamel matrix derivative was applied in conjunction with a gingival graft. Both cases demonstrated a successful and rapid wound closure at the 1-week post-treatment. CONCLUSION: Using autogenous soft tissue grafting should be considered a treatment alternative when dealing with a chronic and problematic open wound. This study describes the success of two cases utilizing this approach. However, an understanding of the biological process of wound healing is critical when selecting a surgical technique for the treatment of a chronic wound. KEY POINTS: There is limited information in the periodontal literature about the management of chronic wounds caused by trauma. Critical understanding of the biological process of wound healing and application of surgical principles are essential in using autogenous soft tissue grafts to treat these wounds. Surgical factors such as extent, location of wound, and limited amount of autogenous donor tissue are primary limitations to the successful treatment of these cases. PLAIN LANGUAGE SUMMARY: Two cases that presented chronic wounds related to the periodontal tissues which were the result of surgical trauma are reported. These complicated healing wounds were managed with free autogenous soft tissue grafts. The grafts assisted the problematic wounds in healing by replacing missing tissue and providing growth factors. This mode of treatment for a chronic wound proved to be a successful approach in the management of this type of chronic wound.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.676
Threshold uncertainty score0.719

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.057
GPT teacher head0.486
Teacher spread0.429 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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