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Prevalence of Impairing Substance Use in Injured Drivers

2025· article· en· W4409666491 on OpenAlexafffundabout
Jeffrey R. Brubacher, Shannon Erdelyi, Herbert Chan, Sarah Simmons, Paul Atkinson, Floyd Besserer, David B. Clarke, Philip J. Davis, Raoul Daoust, Marcel Émond, Jacques Lee, Andrew MacPherson, Kirk Magee, Éric Mercier, Robert Ohle, Mike Parsons, Brian H. Rowe, John A.M. Taylor, Christian Vaillancourt, Ian Wishart

Bibliographic record

VenueJAMA Network Open · 2025
Typearticle
Languageen
FieldPharmacology, Toxicology and Pharmaceutics
TopicForensic Toxicology and Drug Analysis
Canadian institutionsUniversity of CalgaryUniversity of OttawaMemorial University of NewfoundlandUniversity of AlbertaUniversité LavalUniversité de MontréalUniversity of SaskatchewanUniversity of Northern British ColumbiaUniversity of TorontoDalhousie UniversitySaint John Regional HospitalNOSM UniversityUniversity of British Columbia
FundersCanadian Institutes of Health Research
KeywordsCannabisMedicineLogistic regressionDrugPoison controlInjury preventionCross-sectional studyDriving under the influenceDrug classBlood alcoholEnvironmental healthPsychiatryInternal medicine

Abstract

fetched live from OpenAlex

Importance: Impaired driving is an important public health issue, but its prevalence is challenging to monitor. Objectives: To report the prevalence of alcohol, cannabis, recreational drugs, and sedating medications in injured Canadian drivers, identify demographic and collision factors associated with drug or alcohol use, and compare the prevalence of drug-involved driving in different parts of Canada. Design, Setting, and Participants: This cross-sectional study prospectively obtained blood samples from injured drivers treated in 15 Canadian trauma centers and measured blood levels of tetrahydrocannabinol (THC; the main impairing compound in cannabis), alcohol, stimulants, opioids, and depressants from January 2019 to June 2023. Data were analyzed from April to May 2024. Exposure: Blood levels of THC, alcohol, stimulants, opioids, and depressants. Main Outcomes and Measures: Demographic and collision details were extracted from medical records. The crude prevalence for each substance class among all injured drivers and in selected subgroups was computed. Logistic regression models identified factors associated with substance use. Results: Of 8328 injured drivers (mean [SD] age, 43 [18] years; median [IQR] age, 40 [28-57] years; 5605 male [67.3%]; 2723 female [32.7%]), 4568 (54.9%) tested positive for an impairing substance and 1798 (21.6%) tested positive for 2 or more substance classes. Depressants, as a class, were detected in 2368 drivers (28.4%). THC was the most commonly detected single substance (1354 drivers [16.3%]), followed by alcohol (1341 drivers [16.1%]). Stimulants (1057 drivers [12.7%]) and opioids (905 drivers [10.9%]) were also detected. Substances were detected less often in drivers aged 75 years or older (195 of 455 drivers [42.9%]) and younger than 19 years (149 of 304 drivers [49.0%]). THC was most common in drivers aged 19 to 24 years, alcohol in drivers aged 19 to 34 years, stimulants in drivers aged 35 to 44 years, opioids in drivers aged 55 to 64 years, and depressants in drivers aged 65 to 74 years. Males had similar prevalence of substance use as females (3141 males [56.0%] vs 1427 females [52.4%]); more males used alcohol (adjusted odds ratio [aOR], 1.53; 95% CI, 1.21-1.92), cannabis (aOR, 1.66; 95% CI, 1.48-1.86), and stimulants (aOR, 1.53; 95% CI, 1.34-1.75), but males were less likely to have used a depressant (aOR, 0.54; 95% CI, 0.47-0.62). Rural drivers were more likely to use alcohol (aOR, 1.51; 95% CI, 1.29-1.76), stimulants (aOR, 1.32; 95 CI, 1.03-1.70), depressants (aOR, 1.28; 95% CI, 1.09-1.51), opioids (aOR, 1.26; 95% CI, 1.08-1.47), any substance (aOR, 1.40; 95% CI, 1.20-1.63), or multiple classes of substances (aOR, 1.55; 95 CI, 1.23-1.95). There was substantial geographic variation in the prevalence of substance use in injured drivers. Conclusions and Relevance: These findings suggest that impaired driving is a substantial road safety concern in Canada. Continued monitoring is required to develop targeted interventions and to evaluate the effectiveness of prevention measures.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.028
Threshold uncertainty score0.857

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0020.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.075
GPT teacher head0.411
Teacher spread0.337 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations10
Published2025
Admission routes3
Has abstractyes

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