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Record W4409708142 · doi:10.1101/2025.04.16.649223

When Melodies Cue Memories: Electrophysiological Correlates of Autobiographically Salient Music Listening in Older Adults

2025· preprint· en· W4409708142 on OpenAlexafffund
Veronica Vuong, Mary Kay O’Neil, Andrew Dimitrijevic, Bradley R. Buchsbaum, Michael H. Thaut, Claude Alain

Bibliographic record

VenuebioRxiv (Cold Spring Harbor Laboratory) · 2025
Typepreprint
Languageen
FieldNeuroscience
TopicNeuroscience and Music Perception
Canadian institutionsHealth Sciences CentreToronto Rehabilitation InstituteSunnybrook Health Science CentreBaycrest HospitalYork UniversityUniversity of Toronto
FundersNatural Sciences and Engineering Research Council of CanadaAlzheimer's Society
KeywordsMelodyActive listeningPsychologySalientElectrophysiologyAudiologyCognitive psychologyCommunicationNeuroscienceArtComputer scienceMedicineArtificial intelligenceLiteratureMusical

Abstract

fetched live from OpenAlex

Abstract Autobiographical memory is essential for older adults, providing a foundation for self-identity. Healthy aging is accompanied by changes in memory retrieval. However, musical memory remains relatively preserved, suggesting it may serve as an effective cue for autobiographical memory recall. Autobiographically salient (ABS) music (i.e., deeply encoded songs associated to important people, places, and events) is posited to engage distinct memory processes than familiar (FAM) music (i.e., songs that are recognized but lack personal significance). We tested this in 36 older adults (70.6 ± 6.6 years, 20 females) who listened to music of varying degrees of personal significance, including ABS, FAM, and unfamiliar (UFAM) music. In Experiment 1, participants pressed a button as quickly as possible when they recognized the excerpt as ABS, FAM, or UFAM. In Experiment 2, we measured event-related potentials and time-frequency responses while participants listened to the same stimuli and rated familiarity and memory at the end of each excerpt. Participants had the fastest reaction times for ABS, followed by FAM, then UFAM music. We observed a sustained evoked response from 2238 to 5000 ms post-stimulus onset that was largest in amplitude for ABS music, compared to FAM and UFAM music, over right frontal-central regions. We also observed less beta power suppression for ABS than FAM music between 1300 and 5000 ms over bilateral frontal-central-parietal areas. Our behavioral and neurophysiological findings show that ABS music is associated with faster and stronger memory-related activity distinct from FAM music.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.006

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.015
GPT teacher head0.229
Teacher spread0.213 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes2
Has abstractyes

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