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Record W4409830571 · doi:10.14814/phy2.70329

Cross‐education attenuates muscle weakness and facilitates strength recovery after orthopedic immobilization in females: A pilot study

2025· article· en· W4409830571 on OpenAlexaff
Joshua C. Carr, Caleb C. Voskuil, Justin W. Andrushko, Rob J. MacLennan, Jason M. DeFreitas, Matt S. Stock, Jonathan P. Farthing

Bibliographic record

VenuePhysiological Reports · 2025
Typearticle
Languageen
FieldMedicine
TopicSports injuries and prevention
Canadian institutionsUniversity of Saskatchewan
FundersTexas Christian University
KeywordsIsometric exerciseMedicineWeaknessResistance trainingMuscle atrophyMuscle weaknessMuscle strengthPhysical medicine and rehabilitationPhysical therapyLean body massSkeletal muscleSurgeryInternal medicineBody weight

Abstract

fetched live from OpenAlex

This pilot study consists of a two-phase intervention to examine the effectiveness of unilateral resistance training to mitigate the negative consequences of immobilization and expedite the restoration of muscle strength and size following a period of retraining. Ten females were randomized to a unilateral training (TRAIN, n = 6) or control (CON, n = 4) group. During Phase 1, all participants wore an arm sling for a total of 4 weeks on their non-dominant arm. This phase required the TRAIN group to perform unilateral resistance training with the non-immobilized arm while the CON group did not. Phase 2 commenced thereafter and consisted of 4 weeks of bilateral resistance training for both groups. Outcome measures of neuromuscular function and muscle size were assessed at baseline and after each phase, with neuromuscular function quantified by maximal dynamic and isometric strength alongside electromyographic responses and muscle size measured using ultrasonography and regional lean mass via DEXA. Unilateral training of the non-immobilized arm during Phase 1 attenuated dynamic (p < 0.05; g > 1.2), but not isometric (p > 0.40; g < 0.095), strength loss following immobilization and showed large effects for improving the recovery of strength after retraining. Similarly, the imaging data show the relative changes in muscle size and regional lean mass of the non-dominant arm favor TRAIN. Although the small sample prevents definitive conclusions, our study suggests resistance training of the non-immobilized arm attenuates muscle weakness and atrophy for the contralateral, immobilized arm during immobilization and facilitates their recovery following retraining.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.027
Threshold uncertainty score0.453

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.028
GPT teacher head0.340
Teacher spread0.312 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations7
Published2025
Admission routes1
Has abstractyes

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